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Histological analysis of the effects of thymoquinone on testicular damage in pentylenetetrazole-induced temporal lobe epilepsy model

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dc.contributor.authorŞİRVANCI, SERAP
dc.contributor.authorsKarakaya, Fatma Bedia; Yavuz, Melis; Sirvanci, Serap
dc.date.accessioned2022-03-12T22:55:57Z
dc.date.available2022-03-12T22:55:57Z
dc.date.issued2021
dc.description.abstractIn this study, it was aimed to investigate possible ameliorating effects of thymoquinone on testicular damage in an epilepsy model. Adult male Wistar rats were divided into 4 groups. The animals in sham-operated groups were given saline or thymoquinone (s.c.); and the animals in pentylenetetrazole (PTZ) group were applied PTZ. The animals in PTZ+thymoquinone group were given thymoquinone (i.p) for 6 days after applying PTZ. Hematoxylin-eosin, periodic acid-Schiff and TUNEL staining and PCNA, StAR, inhibin beta-B immunohistochemistry and ZO-1 immunofluorescence methods were applied. Staining intensity and cell numbers were determined. Degeneration of seminiferous tubules was observed in PTZ group. Most of the tubules showed normal morphology in the PTZ+thymoquinone group. Apoptotic cell index was found to be increased and proliferative index decreased in PTZ group. Thymoquinone administration decreased apoptotic index and increased proliferation index. In PTZ group, ZO-1, StAR and inhibin beta-B immunohistochemical staining intensity was observed to be decreased and after thymoquinone application, ZO-1 was increased. StAR and inhibin beta-B-positive cell numbers were decreased in PTZ group and increased in the PTZ +thymoquinone group. In this study, it was observed that PTZ-induced epileptic seizures caused testicular damage in the rat and thymoquinone ameliorated these effects.
dc.identifier.doi10.1111/and.14130
dc.identifier.eissn1439-0272
dc.identifier.issn0303-4569
dc.identifier.pubmed34414592
dc.identifier.urihttps://hdl.handle.net/11424/236863
dc.identifier.wosWOS:000686383700001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofANDROLOGIA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectkindling
dc.subjectpentylenetetrazole
dc.subjecttemporal lobe epilepsy
dc.subjecttestis
dc.subjectthymoquinone
dc.subjectGERM-CELL APOPTOSIS
dc.subjectTASK-FORCE
dc.subjectTESTIS
dc.subjectDYSFUNCTION
dc.subjectSEIZURES
dc.subjectCADMIUM
dc.subjectPROTEIN
dc.subjectANTIOXIDANTS
dc.subjectEXPRESSION
dc.subjectFERTILITY
dc.titleHistological analysis of the effects of thymoquinone on testicular damage in pentylenetetrazole-induced temporal lobe epilepsy model
dc.typearticle
dspace.entity.typePublication
local.avesis.idd7fe531c-f4ec-471d-a949-174805d19bbb
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumbere14130
local.journal.numberofpages10
oaire.citation.issue10
oaire.citation.titleANDROLOGIA
oaire.citation.volume53
relation.isAuthorOfPublicationfcdb4c83-6090-4b1e-8758-448d3b32b73a
relation.isAuthorOfPublication.latestForDiscoveryfcdb4c83-6090-4b1e-8758-448d3b32b73a

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