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Phoenixin 14 ameloriates pancreatic injury in streptozotocin-induced diabetic rats by alleviating oxidative burden

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dc.contributor.authorÖZDEMİR KUMRAL, ZARİFE NİGAR
dc.contributor.authorYÜKSEL, MERAL
dc.contributor.authorAKAKIN, DİLEK
dc.contributor.authorERZİK, CAN
dc.contributor.authorHAKLAR, GONCAGÜL
dc.contributor.authorsÖZDEMİR KUMRAL Z. N. , Sen E., Yapici H. B. , Atakul N., Domruk O. F. , Aldag Y., Sen L. S. , Mustafaoglu F. K. , YÜKSEL M., AKAKIN D., et al.
dc.date.accessioned2022-10-10T16:55:03Z
dc.date.available2022-10-10T16:55:03Z
dc.date.issued2022-09-01
dc.description.abstractPhoenixin-14 (PNX) is a neuropeptide that has been shown to prevent oxidative damage and stimulates insulin secretion. We investigated the effects of PNX on pancreatic injury induced by streptozotocin (STZ), and nicotinamide (NAD). Male Sprague-Dawley rats, in control (C) and diabetic (STZ) groups, were treated with either saline, or PNX (0.45 nmol/kg, or 45 nmol/kg) daily for 3 days 1 week after STZ injection. Fasting blood glucose (FBG) and gastric emptying rate (GER) were measured. Tissue and blood samples were collected. PNX treatments prevented pancreatic damage and beta cell loss. Increased luminol and lucigenin levels in the pancreas, ileum and liver tissues of STZ groups were alleviated by PNX treatment in pancreatic and ileal tissues. PNX0.45 decreased FBG without any change in insulin blood level and pancreatic mRNA. GER increased in all diabetic rats while PNX0.45 delayed GER only in the C group. PNX diminishes pancreatic damage and lowers FBG by reducing oxidative load.
dc.identifier.citationÖZDEMİR KUMRAL Z. N. , Sen E., Yapici H. B. , Atakul N., Domruk O. F. , Aldag Y., Sen L. S. , Mustafaoglu F. K. , YÜKSEL M., AKAKIN D., et al., "Phoenixin 14 ameloriates pancreatic injury in streptozotocin-induced diabetic rats by alleviating oxidative burden", JOURNAL OF PHARMACY AND PHARMACOLOGY, 2022
dc.identifier.doi10.1093/jpp/rgac055
dc.identifier.issn0022-3573
dc.identifier.urihttps://hdl.handle.net/11424/282251
dc.language.isoeng
dc.relation.ispartofJOURNAL OF PHARMACY AND PHARMACOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTemel Eczacılık Bilimleri
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectBasic Pharmaceutics Sciences
dc.subjectPharmacology and Therapeutics
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectLife Sciences (LIFE)
dc.subjectFarmakoloji
dc.subjectFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectİlaç Rehberleri
dc.subjectPharmacy
dc.subjectPharmacology
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology (medical)
dc.subjectDrug Guides
dc.subjectinflammation
dc.subjectinsulin
dc.subjectgastric emptying
dc.subjectglucose
dc.subjectfree radicals
dc.subjectMPO
dc.subjectORAL GLUCOSE-TOLERANCE
dc.subjectPEPTIDE
dc.subjectTESTOSTERONE
dc.subjectMODULATION
dc.subjectNESFATIN-1
dc.subjectEXPRESSION
dc.subjectSECRETION
dc.subjectSTRESS
dc.subjectDAMAGE
dc.subjectSITES
dc.subjectinflammation
dc.subjectinsulin
dc.subjectgastric emptying
dc.subjectglucose
dc.subjectfree radicals
dc.subjectMPO
dc.titlePhoenixin 14 ameloriates pancreatic injury in streptozotocin-induced diabetic rats by alleviating oxidative burden
dc.typearticle
dspace.entity.typePublication
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