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Determination of fosfomycin susceptibility in carbapenemase-producing K. pneumoniae strains isolated prior to clinical use of the intravenous formulation in Turkey

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dc.contributor.authorERTÜRK ŞENGEL, BUKET
dc.contributor.authorsAltinkanat Gelmez, Gulsen; Can, Baris; Erturk Sengel, Buket; Korten, Volkan; Soyletir, Guner
dc.date.accessioned2022-03-14T09:34:55Z
dc.date.available2022-03-14T09:34:55Z
dc.date.issued2021-05-25
dc.description.abstractObjectives: The incidence of infections caused by carbapenem-resistant Enterobacteriaceae has increased worldwide. Limitations in the development of new antimicrobial agents have led clinicians to reconsider the clinical efficiency of old antibiotics, such as intravenous formulation of fosfomycin, in the treatment of multidrug-resistant Gram-negative bacterial infections. We investigated the fosfomycin susceptibility of carbapenemase-producing Klebsiella pneurnoniae strains isolated prior to the clinical use of the intraveno US formulation of fosfomycin in Turkey. Materials and Methods: A total of the 155 K. pneurnoniae isolates which previously characterized at the molecular level for their carbapenemase were included in this study. The minimum inhibitory concentration of fosfomycin was determined by the agar dilution method. Results: Overall, 65.1% of the isolates were susceptible to fosfom ycin. The MIC50 and MIC90 values were 32 and 256 mg/L, respectively. According to our results, at least two-third of carbapenemase-positive K. pneumoniae are susceptible to fosfomycin. Conclusions: Although, the susceptibility of fosfomycin, which has just been put into the clinical use of intravenous formulation in Turkey, is not very high, it can be considered as an alternative adjunct antimicrobial for the treatment of systemic infections caused by carbapenentase-positive K. pneumoniae isolates.
dc.identifier.doi10.5472/marumj.942784
dc.identifier.issn1309-9469
dc.identifier.urihttps://hdl.handle.net/11424/243289
dc.identifier.wosWOS:000657549300006
dc.language.isoeng
dc.publisherMARMARA UNIV, FAC MEDICINE
dc.relation.ispartofMARMARA MEDICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFosfomycin susceptibility
dc.subjectCarbapenemase-producing Klebsiella pneumoniae
dc.subjectKLEBSIELLA-PNEUMONIAE
dc.subjectRESISTANT ENTEROBACTERIACEAE
dc.subjectEMERGENCE
dc.subjectCOLISTIN
dc.titleDetermination of fosfomycin susceptibility in carbapenemase-producing K. pneumoniae strains isolated prior to clinical use of the intravenous formulation in Turkey
dc.typearticle
dspace.entity.typePublication
local.avesis.id281df800-310c-46e7-bbc4-f709a230d9a3
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages5
oaire.citation.endPage131
oaire.citation.issue2
oaire.citation.startPage127
oaire.citation.titleMARMARA MEDICAL JOURNAL
oaire.citation.volume34
relation.isAuthorOfPublication67d5b9df-08b7-4c37-b042-45ea89a4c23d
relation.isAuthorOfPublication.latestForDiscovery67d5b9df-08b7-4c37-b042-45ea89a4c23d

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