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Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

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dc.contributor.authorSAKAR, MUSTAFA
dc.contributor.authorsBandyopadhyay S., Peter N., Lakhoo K., Abib S. d. C. V. , Abdelhafeez H., Wilson S., Pachl M., Martin B., Nagras S., Sheth M., et al.
dc.date.accessioned2022-12-19T07:25:51Z
dc.date.available2022-12-19T07:25:51Z
dc.date.issued2022-10-01
dc.description.abstractIntroduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin\"s lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68); p<0.001), lower middle income (OR 3.32 (95% CI 1.96 to 5.61); p<0.001) and upper middle income (OR 3.49 (95% CI 2.02 to 6.03); p<0.001) country status and chemotherapy (OR 0.55 (95% CI 0.36 to 0.86); p=0.008) and immunotherapy (OR 0.27 (95% CI 0.08 to 0.91); p=0.035) within 30 days from MDT plan. Multivariable analysis revealed laboratory-confirmed SARS-CoV-2 infection (OR 5.33 (95% CI 1.19 to 23.84); p=0.029) was associated with 30-day mortality. Conclusions Children with cancer are more likely to die within 30 days if infected with SARS-CoV-2. However, timely treatment reduced odds of death. This report provides crucial information to balance the benefits of providing anticancer therapy against the risks of SARS-CoV-2 infection in children with cancer.
dc.identifier.citationBandyopadhyay S., Peter N., Lakhoo K., Abib S. d. C. V. , Abdelhafeez H., Wilson S., Pachl M., Martin B., Nagras S., Sheth M., et al., "Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic", BMJ GLOBAL HEALTH, cilt.7, sa.10, 2022
dc.identifier.doi10.1136/bmjgh-2022-008797
dc.identifier.issn2059-7908
dc.identifier.issue10
dc.identifier.urihttps://hdl.handle.net/11424/283686
dc.identifier.volume7
dc.language.isoeng
dc.relation.ispartofBMJ GLOBAL HEALTH
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSosyal ve Beşeri Bilimler
dc.subjectSosyoloji
dc.subjectSocial Sciences and Humanities
dc.subjectSociology
dc.subjectKAMU, ÇEVRE VE İŞ SAĞLIĞI
dc.subjectSosyal Bilimler Genel
dc.subjectSosyal Bilimler (SOC)
dc.subjectPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
dc.subjectSOCIAL SCIENCES, GENERAL
dc.subjectSocial Sciences (SOC)
dc.subjectİş Sağlığı ve Terapisi
dc.subjectGüvenlik Araştırması
dc.subjectSağlık (sosyal bilimler)
dc.subjectGenel Sosyal Bilimler
dc.subjectHalk, Çevre ve İş Sağlığı
dc.subjectEpidemiyoloji
dc.subjectSağlık Bilimleri
dc.subjectSosyal Bilimler ve Beşeri Bilimler
dc.subjectOccupational Therapy
dc.subjectSafety Research
dc.subjectHealth (social science)
dc.subjectGeneral Social Sciences
dc.subjectPublic Health, Environmental and Occupational Health
dc.subjectEpidemiology
dc.subjectHealth Sciences
dc.subjectSocial Sciences & Humanities
dc.subjectPaediatrics
dc.subjectCancer
dc.subjectHealth systems
dc.subjectCOVID-19
dc.subjectCHILDHOOD-CANCER
dc.subjectPEDIATRIC CANCER
dc.subjectLOW-INCOME
dc.subjectCARE
dc.subjectMORTALITY
dc.subjectSURVIVAL
dc.subjectRISK
dc.subjectADOLESCENTS
dc.subjectREGISTRIES
dc.subjectIMPACT
dc.titleTwelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic
dc.typearticle
dspace.entity.typePublication
local.avesis.id8421e26b-c992-4217-99e6-0e1422f5a3a3
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationaded309d-d4de-460c-ae87-6fecd672024b
relation.isAuthorOfPublication.latestForDiscoveryaded309d-d4de-460c-ae87-6fecd672024b

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