Publication:
The Role of Vocal Fold Bowing on Cough and Swallowing Dysfunction in Progressive Supranuclear Palsy

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dc.contributor.authorENVER, NECATİ
dc.contributor.authorsEnver, Necati; Borders, James C.; Curtis, James A.; Sevitz, Jordanna S.; Vanegas-Arroyave, Nora; Troche, Michelle S.
dc.date.accessioned2022-03-12T22:43:23Z
dc.date.available2022-03-12T22:43:23Z
dc.date.issued2021
dc.description.abstractObjectives: Progressive supranuclear palsy (PSP) is a neurodegenerative disease which results in cough and swallowing dysfunction and aspiration pneumonia. Relationships among vocal fold atrophy, cough, and swallowing have been identified in related diseases, but remain unknown in PSP. This study examined: 1) the prevalence of vocal fold bowing in PSP, and 2) the influence of vocal fold bowing on cough and swallowing in PSP. Study Design: Prospective Cohort Study. Methods: Twenty-three participants with PSP completed instrumental assessments of cough and swallowing. Vocal fold bowing (BI) and swallowing safety (PAS) was assessed using flexible laryngoscopy. Measures of cough effectiveness were obtained using spirometry. Statistical analyses were used to determine the frequency of mild-moderate (BI > 0) and severe (BI > 12.2) bowing, and to assess the influence of BI on PAS and cough effectiveness in PSP. Results: Fifty-two percent (n = 12) of participants exhibited severe bowing while 48% (n = 11) exhibited mild-to-moderate bowing. Voluntary cough peak expiratory flow rate (P= .01), as well as reflex (P= .02) and voluntary (P= .005) cough volume acceleration were lower for participants with severe BI when compared to mild-to-moderate BI. However, BI did not influence PAS (P> .05). Conclusions: Findings from this study suggest that vocal fold bowing is highly prevalent in PSP and associated with reduced reflex and voluntary cough effectiveness. These findings provide insight into the pathophysiology of compromised airway protection in this patient population. Future studies should examine vocal fold atrophy as a treatment target for behavioral and medical intervention in PSP.
dc.identifier.doi10.1002/lary.28885
dc.identifier.eissn1531-4995
dc.identifier.issn0023-852X
dc.identifier.pubmed32687232
dc.identifier.urihttps://hdl.handle.net/11424/236316
dc.identifier.wosWOS:000550388300001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofLARYNGOSCOPE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectProgressive supranuclear palsy
dc.subjectaspiration
dc.subjectcough
dc.subjectvocal fold atrophy
dc.subjectbowing index
dc.subjectlaryngoscopy
dc.subjectABNORMALITIES
dc.subjectDYSPHAGIA
dc.titleThe Role of Vocal Fold Bowing on Cough and Swallowing Dysfunction in Progressive Supranuclear Palsy
dc.typearticle
dspace.entity.typePublication
local.avesis.id2eb15890-d64a-4b44-b465-18474a8d5071
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ1
oaire.citation.endPage1222
oaire.citation.issue6
oaire.citation.startPage1217
oaire.citation.titleLARYNGOSCOPE
oaire.citation.volume131
relation.isAuthorOfPublication47e0392d-e1ee-45d3-8f90-9dbccd94970b
relation.isAuthorOfPublication.latestForDiscovery47e0392d-e1ee-45d3-8f90-9dbccd94970b

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