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Clarithromycin reduces recurrent cardiovascular events in subjects without periodontitis

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dc.contributor.authorDOĞAN, BAŞAK
dc.contributor.authorsPaju, Susanna; Pussinen, Pirkko J.; Sinisalo, Juha; Mattila, Kimmo; Dogan, Basak; Ahlberg, Jari; Valtonen, Ville; Nieminen, Markku S.; Asikainen, Sirkka
dc.date.accessioned2022-03-12T17:22:17Z
dc.date.available2022-03-12T17:22:17Z
dc.date.issued2006
dc.description.abstractInflammation leading to acute coronary syndrome may be triggered by bacteria causing periodontal infection. We investigated if recurrence of cardiovascular events in unstable coronary patients are associated with periodontitis or microbiological/serological markers of it. Periodontitis-related parameters of 141 patients with acute non-Q-wave infarction or unstable angina pectoris, who participated in a double-blind, placebo-controlled study with clarithromycin for 3 months, were adjusted to the occurrence of a recurrent cardiovascular event during a follow-up period (average 519 days). In the age group under 65 years the patients with periodontitis had a univariate odds ratios (OR) 95% confidence intervals (95% CI) of 5.0 (1.02-24.55) for a recurrent cardiovascular event in comparison with patients without periodontitis. Dental status correlated positively with serum lipopolysaccharide concentrations and combined IgG antibody response to Actinobacillus actinoinycetemcomitans and Porphyromonas gingivalis. The end point frequency did not differ between clarithromycin and placebo groups in bacterium-positive, seropositive, or periodontitis patients. Fewer end points in clarithromycin group were seen in bacterium-negative, seronegative, edentulous, and non-periodontitis patients. Periodontitis and edentulousness are associated with recurrent cardiovascular events, especially in younger patients. Long-term clarithromycin therapy seems to be beneficial in prevention of recurrent cardiovascular events in non-periodontitis but not in periodontitis patients. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.doi10.1016/j.atherosclerosis.2005.11.019
dc.identifier.issn0021-9150
dc.identifier.pubmed16388809
dc.identifier.urihttps://hdl.handle.net/11424/228402
dc.identifier.wosWOS:000240933300025
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTD
dc.relation.ispartofATHEROSCLEROSIS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectinflammation
dc.subjectcoronary disease
dc.subjectacute coronary syndrome
dc.subjectperiodontitis
dc.subjectlipopolysaccharide
dc.subjectCORONARY-HEART-DISEASE
dc.subjectACUTE MYOCARDIAL-INFARCTION
dc.subjectORAL INFECTIONS
dc.subjectASSOCIATION
dc.subjectPATHOGENS
dc.subjectEPIDEMIOLOGY
dc.subjectERYTHROMYCIN
dc.subjectANTIBIOTICS
dc.subjectPREVENTION
dc.subjectANTIBODIES
dc.titleClarithromycin reduces recurrent cardiovascular events in subjects without periodontitis
dc.typearticle
dspace.entity.typePublication
local.avesis.id88e77dbe-c82e-4898-9946-31149385e866
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages8
oaire.citation.endPage419
oaire.citation.issue2
oaire.citation.startPage412
oaire.citation.titleATHEROSCLEROSIS
oaire.citation.volume188
relation.isAuthorOfPublicationa2569f78-7a2a-4f98-8cc9-d8b67ae56f6d
relation.isAuthorOfPublication.latestForDiscoverya2569f78-7a2a-4f98-8cc9-d8b67ae56f6d

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