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Glioblastoma cell adhesion properties through bacterial cellulose nanocrystals in polycaprolactone/gelatin electrospun nanofibers

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dc.contributor.authorYILMAZ, BETÜL
dc.contributor.authorsUnal, Semra; Arslan, Sema; Yilmaz, Betul Karademir; Kazan, Dilek; Oktar, Faik Nuzhet; Gunduz, Oguzhan
dc.date.accessioned2022-03-12T22:40:17Z
dc.date.available2022-03-12T22:40:17Z
dc.date.issued2020
dc.description.abstractGlioblastoma (GBM), the most common and extremely lethal type of brain tumor, is resistant to treatment and shows high recurrence rates. In the last decades, it is indicated that standard two-dimensional (2D) cell culture is inadequate to improve new therapeutic strategies and drug development. Hence, well-mimicked three-dimensional (3D) tumor platforms are needed to bridge the gap between in vitro and in vivo cancer models. In this study, bacterial cellulose nano-crystal (BCNC) containing polycaprolactone (PCL) /gelatin (Gel) nanofibrous composite scaffolds were successfully fabricated by electrospinning for mimicking the extracellular matrix of GBM tumor. The fiber diameters in the nanofibrous matrix were increased with an increased concentration of BCNC. Moreover, fiber morphology changed from the smooth formation to the beaded formation by increasing the concentration of the BCNC suspension. In-vitro biocompatibilities of nanofibrous scaffolds were tested with U251 MG glioblastoma cells and improved cell adhesion and proliferation was compared with PCL/Gel. PCL/Gel/BCNC were found suitable for enhancing axon growth and elongation supporting communication between tumor cells and the microenvironment, triggering the process of tumor recurrence. Based on these results, PCL/Gel/BCNC composite scaffolds are a good candidate for biomimetic GBM tumor platform.
dc.identifier.doi10.1016/j.carbpol.2019.115820
dc.identifier.eissn1879-1344
dc.identifier.issn0144-8617
dc.identifier.pubmed32059880
dc.identifier.urihttps://hdl.handle.net/11424/235934
dc.identifier.wosWOS:000513914400006
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofCARBOHYDRATE POLYMERS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBacterial cellulose nano-crystal
dc.subjectThree-dimensional scaffold
dc.subjectGlioblastoma tumor model
dc.subjectExtracellular matrix
dc.subjectPolycaprolactone
dc.subjectGelatin
dc.subjectMECHANICAL-PROPERTIES
dc.subjectHYALURONIC-ACID
dc.subjectSCAFFOLDS
dc.subjectFABRICATION
dc.subjectHYDROGEL
dc.subjectMATRIX
dc.subjectNANOWHISKERS
dc.subjectCOMPOSITES
dc.subjectMEMBRANES
dc.subjectFIBERS
dc.titleGlioblastoma cell adhesion properties through bacterial cellulose nanocrystals in polycaprolactone/gelatin electrospun nanofibers
dc.typearticle
dspace.entity.typePublication
local.avesis.id33dbab6f-7f9e-4bd9-8d9c-8f6c25f2e4f6
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber115820
local.journal.numberofpages12
local.journal.quartileQ1
oaire.citation.titleCARBOHYDRATE POLYMERS
oaire.citation.volume233
relation.isAuthorOfPublication81633a07-e5fb-4760-b3ef-bf0878d87827
relation.isAuthorOfPublication.latestForDiscovery81633a07-e5fb-4760-b3ef-bf0878d87827

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