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Resveratrol treatment reduces apoptosis and morphological alterations in cisplatin induced testis damage

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsOzyilmaz Yay, Nagehan; Sener, Goksel; Ercan, Feriha
dc.date.accessioned2022-03-14T09:08:37Z
dc.date.available2022-03-14T09:08:37Z
dc.date.issued2019-07-15
dc.description.abstractCisplatin commonly used as a chemotheropotic agent however, it is associated with numerous side effects such as reproductive cytotoxicity. It causes spermatogenic cell death and DNA damage in spermatozoa via the formation of reactive oxygene species. Resveratrol (3,5,4'-trans-trihydroxystilbene), a natural phytoalexin, is a potent antioxidant agent, present in a wide variety of dietary sources including grapes, plums and peanuts. The aim of present study to evaluate the beneficial effects of resveratrol on cisplatin induced testis damage. Male Sprague Dawley rats were used in the study and four experimental groups were formed as: 1- saline applied control, 2- resveratrol applied control, 3- cisplatin and 4- cisplatin+resveratrol groups. Following a single dose of cisplatin (7 mg/kg i.p.), either saline or resveratrol (10 mg/kg, orally) was administered for 5 days. Testis samples were prepared for histopathological and ultrastructural evaluations, cell proliferation and apoptosis. Tissue malondialdehyde (MDA), glutathione (GSH) levels and myeloperoxidase (MPO) activity were determined biochemically. Degenerated and atrophic tubules of tissue, apoptotic cells, MDA level and MPO activity were increased although proliferation index and GSH level were decreased in cisplatin group. Degenerated tight junctions between the Sertoli cells and vacuole formation in germinal epithelial cells were also revealed at this group. However, resveratrol treatment reduced degenerated and atrophic tubules, apoptotic cells, vacuole formation in germinal epithelial cells, MDA level and MPO activity and increased proliferation index and GSH level in testis. These results showed that resveratrol ameliorates cisplatin induced testis injury by the impairment of oxidative stress and apoptosis.
dc.identifier.doi10.12991/jrp.2019.170
dc.identifier.issn2630-6344
dc.identifier.urihttps://hdl.handle.net/11424/242621
dc.identifier.wosWOS:000476616000004
dc.language.isoeng
dc.publisherMARMARA UNIV
dc.relation.ispartofJOURNAL OF RESEARCH IN PHARMACY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCisplatin
dc.subjectresveratrol
dc.subjecttestis
dc.subjectapoptosis
dc.subjectcell proliferation
dc.subjectultrastructure
dc.subjectINDUCED TESTICULAR DAMAGE
dc.subjectINDUCED CARDIOTOXICITY
dc.subjectINDUCED TOXICITY
dc.subjectL-CARNITINE
dc.subjectRATS
dc.subjectBLEOMYCIN
dc.subjectETOPOSIDE
dc.subjectMELATONIN
dc.subjectKIDNEY
dc.subjectINJURY
dc.titleResveratrol treatment reduces apoptosis and morphological alterations in cisplatin induced testis damage
dc.typearticle
dspace.entity.typePublication
local.avesis.id2ec3a25f-8abe-4ddc-8286-b1ffcbde422d
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
local.journal.numberofpages11
oaire.citation.endPage631
oaire.citation.issue4
oaire.citation.startPage621
oaire.citation.titleJOURNAL OF RESEARCH IN PHARMACY
oaire.citation.volume23
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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