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In Vivo Assessment of Bone Enhancement in the Case of 3D-Printed Implants Functionalized with Lithium-Doped Biological-Derived Hydroxyapatite Coatings: A Preliminary Study on Rabbits

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dc.contributor.authorOKTAR, FAİK NÜZHET
dc.contributor.authorsDuta, Liviu; Neamtu, Johny; Melinte, Razvan P.; Zureigat, Oana A.; Popescu-Pelin, Gianina; Chioibasu, Diana; Oktar, Faik N.; Popescu, Andrei C.
dc.date.accessioned2022-03-14T09:26:19Z
dc.date.available2022-03-14T09:26:19Z
dc.date.issued2020-10-17
dc.description.abstractWe report on biological-derived hydroxyapatite (HA, of animal bone origin) doped with lithium carbonate (Li-C) and phosphate (Li-P) coatings synthesized by pulsed laser deposition (PLD) onto Ti6Al4V implants, fabricated by the additive manufacturing (AM) technique. After being previously validated by in vitro cytotoxicity tests, the Li-C and Li-P coatings synthesized onto 3D Ti implants were preliminarily investigated in vivo, by insertion into rabbits' femoral condyles. The in vivo experimental model for testing the extraction force of 3D metallic implants was used for this study. After four and nine weeks of implantation, all structures were mechanically removed from bones, by tensile pull-out tests, and coatings' surfaces were investigated by scanning electron microscopy. The inferred values of the extraction force corresponding to functionalized 3D implants were compared with controls. The obtained results demonstrated significant and highly significant improvement of functionalized implants' attachment to bone (p-values <= 0.05 and <= 0.00001), with respect to controls. The correct placement and a good integration of all 3D-printed Ti implants into the surrounding bone was demonstrated by performing computed tomography scans. This is the first report in the dedicated literature on the in vivo assessment of Li-C and Li-P coatings synthesized by PLD onto Ti implants fabricated by the AM technique. Their improved mechanical characteristics, along with a low fabrication cost from natural, sustainable resources, should recommend lithium-doped biological-derived materials as viable substitutes of synthetic HA for the fabrication of a new generation of metallic implant coatings.
dc.identifier.doi10.3390/coatings10100992
dc.identifier.eissn2079-6412
dc.identifier.urihttps://hdl.handle.net/11424/243121
dc.identifier.wosWOS:000584223900001
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofCOATINGS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbiological-derived hydroxyapatite coatings
dc.subjectlithium doping
dc.subjectfood industrial by-products
dc.subjectin vivo extraction force
dc.subjectpulsed laser deposition
dc.subject3D printing
dc.subjectMAGNESIUM-ENRICHED HYDROXYAPATITE
dc.subjectTHIN-FILMS
dc.subjectMETALLIC IMPLANTS
dc.subjectGENE-EXPRESSION
dc.subjectPORCINE BONE
dc.subjectSTEM-CELLS
dc.subjectDIFFERENTIATION
dc.subjectDEPOSITION
dc.titleIn Vivo Assessment of Bone Enhancement in the Case of 3D-Printed Implants Functionalized with Lithium-Doped Biological-Derived Hydroxyapatite Coatings: A Preliminary Study on Rabbits
dc.typearticle
dspace.entity.typePublication
local.avesis.id51b64f04-7f5b-40f3-b555-7c594baae062
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber992
local.journal.numberofpages21
local.journal.quartileQ2
oaire.citation.issue10
oaire.citation.titleCOATINGS
oaire.citation.volume10
relation.isAuthorOfPublication5ba0a0e0-ebae-43a6-855c-0aabb90021f4
relation.isAuthorOfPublication.latestForDiscovery5ba0a0e0-ebae-43a6-855c-0aabb90021f4

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