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Anti-N-Methyl-d-Aspartate (Anti-NMDA) Receptor Encephalitis Rapid and Sustained Clinical Improvement With Steroid Therapy Starting in the Late Phase

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dc.contributor.authorTÜRKDOĞAN, DİLŞAD
dc.contributor.authorsTurkdogan, Dilsad; Orengul, A. Cahid; Zaimoglu, Sennur; Ekinci, Gazanfer
dc.date.accessioned2022-03-13T12:44:31Z
dc.date.available2022-03-13T12:44:31Z
dc.date.issued2014
dc.description.abstractAnti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis is an autoimmune/paraneoplastic encephalitis, with neurologic and psychiatric symptoms. Early and aggressive therapy has been shown to improve prognosis although problems with executive functions and memory have continued for several years. A 15-year-old girl had a history of initial symptoms including behavioral difficulties, poor attention, and frequent seizures progressing to a catatonia-like state, 2.5 months after onset of initial symptoms. Anti-NMDA receptor antibodies were detected in serum and cerebrospinal fluid. Subsequent to treatment with methylprednisolone starting 3 months after onset, motor skills, responsiveness, self-care, and speech improved rapidly. Her neuropsychologica profile assessed after 2 months showed global difficulties predominantly in attention, executive functions, memory, and visual perception, which moderately recovered in the 7th and 24th months, respectively. Contrary to current literature supporting the positive impact of early immunomodulatory therapy, a dramatic resolution of major neurologic and psychiatric symptoms was detected with steroid treatment given in the late phase.
dc.identifier.doi10.1177/0883073813520497
dc.identifier.eissn1708-8283
dc.identifier.issn0883-0738
dc.identifier.pubmed24563473
dc.identifier.urihttps://hdl.handle.net/11424/237553
dc.identifier.wosWOS:000335090400016
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS INC
dc.relation.ispartofJOURNAL OF CHILD NEUROLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcortical atrophy
dc.subjectsteroid treatment
dc.subjectautoimmune encephalitis
dc.subjectBRAIN ATROPHY
dc.subjectCHILDREN
dc.subjectEXPERIENCE
dc.titleAnti-N-Methyl-d-Aspartate (Anti-NMDA) Receptor Encephalitis Rapid and Sustained Clinical Improvement With Steroid Therapy Starting in the Late Phase
dc.typearticle
dspace.entity.typePublication
local.avesis.id6bba815e-04f7-4ad9-be92-5e2116b26667
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages4
oaire.citation.endPage687
oaire.citation.issue5
oaire.citation.startPage684
oaire.citation.titleJOURNAL OF CHILD NEUROLOGY
oaire.citation.volume29
relation.isAuthorOfPublication0a1599c4-48ff-4aa9-b689-3927c986a650
relation.isAuthorOfPublication.latestForDiscovery0a1599c4-48ff-4aa9-b689-3927c986a650

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