Publication:
Outcome of preemptive penile rehabilitation before bilateral cavernosal nerve injury in rats

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dc.contributor.authorŞİMŞEK, FERRUH
dc.contributor.authorsTavukcu, Hasan Huseyin; Akbal, Cem; Tinay, Ilker; Simsek, Ferruh; Turkeri, Levent
dc.date.accessioned2022-03-12T17:47:22Z
dc.date.available2022-03-12T17:47:22Z
dc.date.issued2010
dc.description.abstractIn this study, prophylactic penile rehabilitation (PR) with sildenafil before and after a cavernosal nerve (CN) injury was analyzed in an animal model. Thirty-six animals were divided into six groups as follows: (1) those with no CN injury (i.e., sham), (2) those with a bilateral CN injury (i.e., control), (3, 4) those with a bilateral CN injury treated with 10-20 mg/kg of sildenafil subcutaneously (SC) on a daily basis commencing 1 month prior to and after nerve injuries, respectively, (5, 6) those with a bilateral CN injury treated daily with 10-20 mg/kg of sildenafil SC after the nerve injuries, respectively. Mean arterial pressure (MAP) and intracavernosal pressure (ICP) were measured in response to CN stimulation to assess erectile function (EF). Neuronal nitric oxide synthase (nNOS) immunohistochemical analysis and real-time polymerase chain reaction (RT-PCR) were performed. The maximal ICP/MAP ratio was 60 +/- A 18% in the sham, 22 +/- A 5% in the control, 28 +/- A 9% in Group III, 45 +/- A 16% in Group IV, 45 +/- A 17% in Group V, and 49 +/- A 21% in Group VI. Although EF was improved with sildenafil treatment in a dose-dependent fashion, no statistically significant difference was observed between the preemptive and standard rehabilitation groups. Again, nNOS immunoreactivity and RT-PCR results showed the beneficial effect of sildenafil, but the study did not support the efficacy of preemptive rehabilitation when compared to the standard rehabilitation group. Although, a dose-response relationship was observed for PR treatment with sildenafil; i.e., outcomes improved at higher doses of sildenafil for PR, preemptive PR should not be pursued as an alternative rehabilitation modality.
dc.identifier.doi10.1007/s00345-009-0495-9
dc.identifier.eissn1433-8726
dc.identifier.issn0724-4983
dc.identifier.pubmed20012747
dc.identifier.urihttps://hdl.handle.net/11424/229739
dc.identifier.wosWOS:000283671800014
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofWORLD JOURNAL OF UROLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCavernosal nerve
dc.subjectPenile rehabilitation
dc.subjectPDE-5 inhibitors
dc.subjectRADICAL PROSTATECTOMY
dc.subjectERECTILE DYSFUNCTION
dc.subjectSEXUAL FUNCTION
dc.subjectSMOOTH-MUSCLE
dc.subjectPRESERVATION
dc.subjectRESECTION
dc.subjectMODEL
dc.titleOutcome of preemptive penile rehabilitation before bilateral cavernosal nerve injury in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id6318da6e-d524-42ff-a09d-8f40df3e10d0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage740
oaire.citation.issue6
oaire.citation.startPage735
oaire.citation.titleWORLD JOURNAL OF UROLOGY
oaire.citation.volume28
relation.isAuthorOfPublicationb91c9805-ef29-4cda-82ba-4b4da6191e26
relation.isAuthorOfPublication.latestForDiscoveryb91c9805-ef29-4cda-82ba-4b4da6191e26

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