Publication: The role of myocardial performance index and Nt-proBNP levels as a marker of heart dysfunction in nonalcoholic cirrhotic patients
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Date
2022-01-01
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Abstract
Objective: Cardiac dysfunction has been reported in both cirrhotic and alcoholic patients. Our aim was to determine the relation of
serum N-terminal pro-B-type natriuretic peptide (Nt-proBNP) levels to myocardial performance index (MPI) and disease severity
in nonalcoholic cirrhotic patients.
Patients and Methods: In this prospective study including 25 cirrhotic patients and 27 healthy controls, MPI was assessed by pulsedwave tissue Doppler imaging (PW-TDI). The disease severity was determined by Child–Turcotte–Pugh (CTP ) and model for endstage liver disease (MELD) scores.
Results: There were no statistically significant differences in MPI levels between patients and controls (p< 0.246). Nt-proBNP levels
(p< 0.0003), cardiac output (CO) (p< 0.0002), left ventricular end-systolic (LVES) volume (p< 0.031) and QT interval (p< 0.0001)
increased and left ventricular systolic function was normal in all cirrhotic patients when compared to controls. Nt-proBNP levels were
positively correlated with MELD scores (p< 0.0001, r= 0.59), QT duration (p< 0.0001, r= 0.59), CO (p= 0,001, r= 0.44), right atrial
(RA) area (p= 0.026, r= 0.31) and negatively correlated with diastolic BP (p= 0.015, r= – 0.34).
Conclusion: We conclude that in nonalcoholic cirrhotic patients, left ventricular MPI and systolic function were normal. Nt-proBNP
levels were correlated with the disease severity and hyperdynamic circulation.
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Keywords
Tıp, Sağlık Bilimleri, Temel Tıp Bilimleri, Medicine, Health Sciences, Fundamental Medical Sciences, TIP, GENEL & DAHİLİ, Klinik Tıp, Klinik Tıp (MED), MEDICINE, GENERAL & INTERNAL, CLINICAL MEDICINE, Clinical Medicine (MED), Family Practice, Fundamentals and Skills, General Health Professions, Pathophysiology, Internal Medicine, Assessment and Diagnosis, Medicine (miscellaneous), General Medicine, Cirrhosis, Heart failure, Nt-proBNP, Echocardiography, BRAIN-NATRIURETIC PEPTIDE, VENTRICULAR DIASTOLIC DYSFUNCTION, TISSUE-DOPPLER, EUROPEAN ASSOCIATION, AMERICAN SOCIETY, FILLING PRESSURE, TEI INDEX, CARDIOMYOPATHY, ECHOCARDIOGRAPHY, SEVERITY, Cirrhosis, Heart failure, Nt-proBNP, Echocardiography
Citation
TOKAY TARHAN S., Yilmaz Enc F., EREN F., FAK A. S., Ozdogan O., "The role of myocardial performance index and Nt-proBNP levels as a marker of heart dysfunction in nonalcoholic cirrhotic patients", MARMARA MEDICAL JOURNAL, cilt.35, sa.1, ss.10-16, 2022