Publication:
Hepatoprotective effects of parsley (Petroselinum Crispum) extract in rats with bile duct ligation

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dc.contributor.authorÖZBEYLİ, DİLEK
dc.contributor.authorERCAN, FERİHA
dc.contributor.authorYÜKSEL, MERAL
dc.contributor.authorsEde S., ÖZBEYLİ D., Erdoğan Ö., Çevik Ö., Kanpalta F., ERCAN F., YANARDAĞ R., SAÇAN Ö., ERTİK O., YÜKSEL M., et al.
dc.date.accessioned2022-12-27T05:59:07Z
dc.date.available2022-12-27T05:59:07Z
dc.date.issued2022-01-01
dc.description.abstract© 2022 Pan-Arab Association of GastroenterologyBackground and study aims: This study aimed to investigate the possible protective effects of parsley extract (Petroselinum Crispum; PC) against oxidative liver damage caused by bile obstruction in rats. Material and methods: Bile duct ligation (BDL) method was used to induce liver injury in rats. The rats were divided into the three groups each consisting of 8 rats; Sham-operated control (C), bile duct ligated + saline treated (BDL), and BDL + PC treated groups. PC extract was given at a dose of 2 g/kg orally for 28 days. Aspartate amino transferase (AST), alanin amino transferase (ALT), and bilirubin levels were analyzed in sera. In order to determine free radicals in liver injury, luminol and lucigenin chemiluminescence tests used. Oxidative stress was evaluated through superoxide dismutase, glutathione, malondialdehyde, Na+/K+-ATPase and 8-hydroxy guanosine levels. Furthermore, inflammation marker myeloperoxidase, apoptosis marker caspase-3, and fibrosis markers TGF- β and hydoxyproline were investigated. The liver tissues were also examined for histological evaluations. Results: While PC treatment decreased AST and ALT levels which increased with BDL, oxidant damage parameters also decreased with this treatment. Conclusion: The present study, which is the first research for PC extract on cholestasis induced liver damage, demonstrated that PC extract could be a potential therapeutic agent against liver fibrosis and need further studies.
dc.identifier.citationEde S., ÖZBEYLİ D., Erdoğan Ö., Çevik Ö., Kanpalta F., ERCAN F., YANARDAĞ R., SAÇAN Ö., ERTİK O., YÜKSEL M., et al., "Hepatoprotective effects of parsley (Petroselinum Crispum) extract in rats with bile duct ligation", Arab Journal of Gastroenterology, 2022
dc.identifier.doi10.1016/j.ajg.2022.10.006
dc.identifier.issn1687-1979
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85141959490&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/284155
dc.language.isoeng
dc.relation.ispartofArab Journal of Gastroenterology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectGastroenteroloji-(Hepatoloji)
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectGastroenterology and Hepatology
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectGASTROENTEROLOJİ VE HEPATOLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectGASTROENTEROLOGY & HEPATOLOGY
dc.subjectGastroenteroloji
dc.subjectGastroenterology
dc.subjectApoptosis
dc.subjectCholestasis
dc.subjectFibrosis
dc.subjectOxidant damage
dc.subjectParsley
dc.titleHepatoprotective effects of parsley (Petroselinum Crispum) extract in rats with bile duct ligation
dc.typearticle
dspace.entity.typePublication
local.avesis.idf96c502b-f07c-4a97-8040-577971c564b0
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication4681bb67-e40b-4cf0-8154-5472237f2325
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication8b13d479-2f3b-4180-bc71-7ad5a5625f1b
relation.isAuthorOfPublication.latestForDiscovery4681bb67-e40b-4cf0-8154-5472237f2325

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