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Combination techniques towards novel drug delivery systems manufacturing: 3D PCL scaffolds enriched with tetracycline-loaded PVP nanoparticles

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dc.contributor.authorCESUR, SÜMEYYE
dc.contributor.authorsCESUR S.
dc.date.accessioned2023-12-18T07:48:30Z
dc.date.available2023-12-18T07:48:30Z
dc.date.issued2024-01-01
dc.description.abstractDrug delivery systems based on synthetic and natural polymers offer a new approach with a capacity to control the release of bio-active agents within time. In this work, we present different designs of Polycaprolactone (PCL) 3D scaffolds containing Polyvinylpyrrolidone (PVP) nanoparticles that can store a hydrophilic drug. The drug delivery system, combined of PCL and PVP polymers fabricated by additive manufacturing, aims for a solution for longer and more stabled drug delivery carrier. The drug, planned to be released to the targeted area, is sprayed with the electrospray method inside PVP nanoparticles on the different layers of the fabricated PCL scaffolds 3D printing. This makes obtaining a layered and porous scaffold and drug-loaded nanoparticles within this structure easier. Obtained PCL scaffolds containing Tetracyclines (Tet) loaded PVP nanoparticles showed that drug encapsulation into the interlayer extended the release time and exhibited a controlled release profile for days. Moreover, produced scaffolds have good biocompatibility and no harmful effects. The combination of 3D scaffolds and drug-loaded nanoparticles aims to develop new functional scaffolds by targeting more efficient and longer-lasting drug delivery.
dc.identifier.citationCESUR S., "Combination techniques towards novel drug delivery systems manufacturing: 3D PCL scaffolds enriched with tetracycline-loaded PVP nanoparticles", European Journal of Pharmaceutics and Biopharmaceutics, cilt.194, ss.36-48, 2024
dc.identifier.doi10.1016/j.ejpb.2023.11.022
dc.identifier.endpage48
dc.identifier.issn0939-6411
dc.identifier.startpage36
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85178477950&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/295713
dc.identifier.volume194
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Pharmaceutics and Biopharmaceutics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectYaşam Bilimleri
dc.subjectBiyoteknoloji
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectLife Sciences
dc.subjectBiotechnology
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectMikrobiyoloji
dc.subjectTROPİKAL TIP
dc.subjectBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectCLINICAL MEDICINE
dc.subjectMICROBIOLOGY
dc.subjectTROPICAL MEDICINE
dc.subjectBIOTECHNOLOGY & APPLIED MICROBIOLOGY
dc.subjectFarmasötik bilim
dc.subjectPharmaceutical Science
dc.subject3D Printing
dc.subjectDrug release modulation
dc.subjectElectrospraying
dc.subjectNanoparticles
dc.subjectScaffolds
dc.titleCombination techniques towards novel drug delivery systems manufacturing: 3D PCL scaffolds enriched with tetracycline-loaded PVP nanoparticles
dc.typearticle
dspace.entity.typePublication
local.avesis.id43a99856-743f-49d0-b509-4631799c6e22
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication155dc947-cf5f-46e3-8ddb-0a1e9751e23f
relation.isAuthorOfPublication.latestForDiscovery155dc947-cf5f-46e3-8ddb-0a1e9751e23f

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