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Fibroblast Growth Factor-23 Levels Are Associated With Uric Acid But Not Carotid Intima Media Thickness in Renal Transplant Recipients

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dc.contributor.authorVELİOĞLU, ARZU
dc.contributor.authorsAsicioglu, E.; Kahveci, A.; Arikan, H.; Koc, M.; Tuglular, S.; Ozener, C.
dc.date.accessioned2022-03-13T12:44:41Z
dc.date.available2022-03-13T12:44:41Z
dc.date.issued2014
dc.description.abstractIntroduction. Cardiovascular disease (CVD) is the leading cause of mortality in chronic kidney disease (CKD) patients. Fibroblast growth factor-23 (FGF-23) is associated with atherosclerosis and cardiovascular mortality in CKD patients and healthy subjects. However, data in renal transplant recipients (RTR) are scarce. We aimed to determine factors associated with FGF-23 and to explore its relationship to atherosclerosis. Methods. Forty-six patients and 44 controls were included. FGF-23 was measured from plasma. Carotid intima media thickness (CIMT) was evaluated ultrasonographically. Results. Patients had higher waist circumference (WC; 92.2 +/- 14.9 vs 85.3 +/- 11.0 cm; P < .05), glucose (99.8 +/- 17.2 vs 90.3 +/- 6.5 mg/dL; P < .01), creatinine (1.43 +/- 0.6 vs 0.86 +/- 0.1 mg/dL; P < .01), triglyceride (160.4 +/- 58.9 vs 135.6 +/- 59.8 mg/dL; P < .05), white blood cells (WBC; 7938.6 +/- 2105.2 vs 6715.7 +/- 1807.5 WBC/mm(3); P < .01), ferritin (217.0 +/- 255.8 vs 108.3 +/- 142.4 ng/mL; P < .05), uric acid (6.5 +/- 1.6 vs 4.7 +/- 1.3 mg/dL; P < .01), C-reactive protein (CRP; 8.2 +/- 18.2 vs 5.3 +/- 7.9 mg/L; P < .01), parathyroid hormone (PTH; 89.7 +/- 59.2 vs 44.1 +/- 16.7 pg/mL; P < .01), and alkaline phosphatase (ALP; 162.5 +/- 86.6 vs 74.2 +/- 21.9 U/L; P < .01). FGF-23 was higher in patients (11.7 +/- 7.2 vs 9.6 +/- 6.8 pg/mL; P < .05). CIMT was similar (0.58 +/- 0.09 vs 0.57 +/- 0.1 mm; P > .05). WC, creatinine, and uric acid were positively correlated with FGF-23, whereas albumin showed negative correlation. On multivariate analysis only creatinine and uric acid were determinants of FGF-23. Conclusion. FGF-23 levels are associated with uric acid in RTR. Larger studies are needed to confirm this finding.
dc.identifier.doi10.1016/j.transproceed.2013.10.043
dc.identifier.eissn1873-2623
dc.identifier.issn0041-1345
dc.identifier.pubmed24507048
dc.identifier.urihttps://hdl.handle.net/11424/237615
dc.identifier.wosWOS:000331596900032
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofTRANSPLANTATION PROCEEDINGS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCHRONIC KIDNEY-DISEASE
dc.subjectHEMODIALYSIS-PATIENTS
dc.subjectCARDIOVASCULAR RISK
dc.subjectENDOTHELIAL FUNCTION
dc.subjectPERITONEAL-DIALYSIS
dc.subjectMORTALITY
dc.subjectALLOPURINOL
dc.subjectDYSFUNCTION
dc.subjectFGF-23
dc.subjectATHEROSCLEROSIS
dc.titleFibroblast Growth Factor-23 Levels Are Associated With Uric Acid But Not Carotid Intima Media Thickness in Renal Transplant Recipients
dc.typearticle
dspace.entity.typePublication
local.avesis.idffdad3c1-241e-4ad8-b61d-d9632cef4d0a
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages4
oaire.citation.endPage183
oaire.citation.issue1
oaire.citation.startPage180
oaire.citation.titleTRANSPLANTATION PROCEEDINGS
oaire.citation.volume46
relation.isAuthorOfPublicationa7410f0e-0eb4-4b83-ad61-a71dfbee164f
relation.isAuthorOfPublication.latestForDiscoverya7410f0e-0eb4-4b83-ad61-a71dfbee164f

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