Publication: Lung Cancer with Oral Cavity Metastasis: Two Case Reports
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Date
2024-08-01
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Abstract
Malign tümörlerin önemli biyolojik ayırt edici özelliklerinden olan invazyon ve metastaz; kansere bağlı
morbidite ve mortalitenin en önemli nedenlerindendir. Oral kavite de görülen metastatik tümörler
oral malign karakterli tümörlerin %1-1.5’ ini oluşturmaktadır ve bu bölgeye metastaz yapan en yaygın
primer odaklar arasında meme, akciğer, böbrek, kemik, prostat ve kolon kanserleri gelmektedir.
Çene kemiklerinde en sık tutulum alanı mandibula posterior iken yumuşak doku tutulumları en sık
dişetine olmaktadır. 63 yaşında erkek hasta mandibula anterior dişlerin çekimi sonrası gelişen, alveol
kemiğe invaze, yüzeyi düzensiz ve ülsere alanlar içeren kitle şikayetiyle başvurmuştur. İnsizyonel
biyopsi ile değerlendirilen kitlenin histopatolojik incelemesinde saydam hücrelerden baskın karsinom
tanısı almıştır. Primer odağın araştırılması için onkoloji servisine yönlendirilmiş ve PET-CT taraması
ile akciğer kanseri teşhisi koyulmuştur. Anamnezinde bir yıl önce akciğer kanseri teşhisi koyulan
ve uzun kemik metastazları bulunan 62 yaş erkek hasta sol mandibulada rezidüel diş kökünden
kaynaklandığını düşündüğü ağrı şikayetiyle başvurmuştur. Yapılan CBCT incelemesinde sol mandibula
ramus bölgesinde inferior alveolar kanalı içine almış, kortikal ve trabekül yapıda güve yeniği tarzında
osteolitik alanlar izlenmiştir. Akciğer kanseri ve uzak organ metastazları bulunan hasta onkoloji
bölümüne yönlendirilmiş ve palyatif tedavisine devam etmiştir. Her iki hasta da 3 ve 6 ay takip
sonunda yaşamını yitirmiştir. Metastazların varlığı kötü prognoza işaret eder ve evrelere göre çeşitli
tedaviler uygulanabilir. Oral kavite de meydana gelen değişimler dikkatle takip edilmeli, gerekli
durumlarda histopatolojik inceleme ile tanıya gidilmelidir.
Anahtar Kelimeler: Oral kavite, oral kanser, akciğer kanseri, histopatoloji, metastaz
Invasion and metastasis, which are important biological hallmarks of malignant tumors, are among the most important causes of cancer-related morbidity and mortality. Metastatic tumors in the oral cavity constitute 1-1.5% of oral malignant tumors and the most common primary foci metastasizing to this region are breast, lung, kidney, bone, prostate and colon cancers. The most common site of involvement in the jaw bones is the mandible posterior, while soft tissue involvement is most common in the gingiva. A 63-year-old male patient presented with a mass invading the alveolar bone with irregular and ulcerated areas after extraction of mandibular anterior teeth. Incisional biopsy was performed and histopathological examination of the mass revealed a diagnosis of carcinoma predominantly composed of clear cells. He was referred to the oncology service for investigation of the primary focus and lung cancer was diagnosed by PET-CT scan. A 62-year-old male patient who was diagnosed with lung cancer one year ago and had long bone metastases in his anamnesis presented with pain in the left mandible, which was thought to be caused by the residual tooth root. CBCT examination revealed moth-eaten osteolytic areas in the cortical and trabecular structure involving the inferior alveolar canal in the ramus region of the left mandible. The patient with lung cancer and distant organ metastases was referred to the oncology department and palliative treatment was continued. Both patients died after 3 and 6 months of follow-up. The presence of metastases indicates a poor prognosis and various treatments can be applied according to the stages. Changes occurring in the oral cavity should be followed carefully and diagnosis should be made by histopathological examination when necessary. Keywords: Indigo naturalis cell viability, periodontal ligament fibroblast.
Invasion and metastasis, which are important biological hallmarks of malignant tumors, are among the most important causes of cancer-related morbidity and mortality. Metastatic tumors in the oral cavity constitute 1-1.5% of oral malignant tumors and the most common primary foci metastasizing to this region are breast, lung, kidney, bone, prostate and colon cancers. The most common site of involvement in the jaw bones is the mandible posterior, while soft tissue involvement is most common in the gingiva. A 63-year-old male patient presented with a mass invading the alveolar bone with irregular and ulcerated areas after extraction of mandibular anterior teeth. Incisional biopsy was performed and histopathological examination of the mass revealed a diagnosis of carcinoma predominantly composed of clear cells. He was referred to the oncology service for investigation of the primary focus and lung cancer was diagnosed by PET-CT scan. A 62-year-old male patient who was diagnosed with lung cancer one year ago and had long bone metastases in his anamnesis presented with pain in the left mandible, which was thought to be caused by the residual tooth root. CBCT examination revealed moth-eaten osteolytic areas in the cortical and trabecular structure involving the inferior alveolar canal in the ramus region of the left mandible. The patient with lung cancer and distant organ metastases was referred to the oncology department and palliative treatment was continued. Both patients died after 3 and 6 months of follow-up. The presence of metastases indicates a poor prognosis and various treatments can be applied according to the stages. Changes occurring in the oral cavity should be followed carefully and diagnosis should be made by histopathological examination when necessary. Keywords: Indigo naturalis cell viability, periodontal ligament fibroblast.
Description
Keywords
Oral kavite, oral kanser, akciğer kanseri, histopatoloji, metastaz, Indigo naturalis cell viability, periodontal ligament fibroblast
Citation
YÜLEK H., KESER G., NAMDAR PEKİNER F. M., "Lung Cancer with Oral Cavity Metastasis: Two Case Reports", European Journal of Research in Dentistry, cilt.8, sa.2, ss.72-76, 2024