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Protective effects of spironolactone against hepatic ischemia/reperfusion injury in rats

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dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsAtalay, Suleyman; Soylu, Belkis; Aykac, Asli; Ogunc, Ayliz Velioglu; Cetinel, Sule; Ozkan, Naziye; Erzik, Can; Sehirli, Ahmet Ozer
dc.date.accessioned2022-04-25T00:11:32Z
dc.date.available2022-04-25T00:11:32Z
dc.date.issued2019
dc.description.abstractObjective: In the present study, it was aimed to study the antioxidant effects of spironolactone (SPL) to determine its possible protective effects in hepatic ischemia reperfusion injury. Material and Methods: Hepatic artery, portal vein, and bile duct of Wistar albino rats were clamped for 45 minutes under anesthesia to form an ischemia period. Then reperfusion was allowed and the rats were decapitated 60 minutes later. SPL (20 mg/kg, p.o.) or SF was orally administered for 30 minutes before ischemia. Rats in the control arm underwent sham surgery and were administered isotonic saline. Liver function was studied by measuring aspartate aminotransferase (AST), alanine aminotransferase (ALT), tumor necrosis factor-alpha (TNF-alpha), and interleukin 1beta (IL-1 beta) levels. Malondialdehyde (MDA), glutathione (GSH), luminol, and lucigenin levels, myeloperoxidase (MPO) and Na+-K+- ATPase enzyme activities were analyzed to study tissue injury under light microscope. Results: While IR increased AST, ALT, TNF-alpha, and IL-1 beta levels and MDA, luminol, and lusigenin levels and MPO activities, it caused a decrease in GSH levels and Na+K+-ATPase activity. Spironolactone administration significantly improved these values. Conclusion: Protective effects of SPL against ischemia/reperfusion injury via various mechanisms suggest that this agent may become a novel treatment agent in clinical practice.
dc.identifier.doi10.5578/turkjsurg.4340
dc.identifier.eissn2564-7032
dc.identifier.issn2564-6850
dc.identifier.pubmed32551425
dc.identifier.urihttps://hdl.handle.net/11424/263924
dc.identifier.wosWOS:000510646300009
dc.languageeng
dc.publisherTURKISH SURGICAL ASSOC
dc.relation.ispartofTURKISH JOURNAL OF SURGERY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHepatic ischemia reperfusion
dc.subjectspironolactone
dc.subjectmalondialdehyde
dc.subjectglutathione
dc.subjectcytokines
dc.subjectISCHEMIA-REPERFUSION INJURY
dc.subjectMELATONIN PROTECTS
dc.subjectLIVER-INJURY
dc.subjectRECEPTORS
dc.subjectAPOPTOSIS
dc.titleProtective effects of spironolactone against hepatic ischemia/reperfusion injury in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.idf5f3a80c-95f0-4be8-a822-e86c3b9b470b
local.import.packageSS39
local.indexed.atWOS
local.journal.numberofpages8
oaire.citation.endPage292
oaire.citation.issue4
oaire.citation.startPage285
oaire.citation.titleTURKISH JOURNAL OF SURGERY
oaire.citation.volume35
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

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