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Caffeic acid phenethyl ester (CAPE) prevents methotrexate-induced hepatorenal oxidative injury in rats

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dc.contributor.authorDULUNDU, ENDER
dc.contributor.authorsCakir, Tugrul; Ozkan, Erkan; Dulundu, Ender; Topaloglu, Umit; Sehirli, Ahmet Ozer; Ercan, Feriha; Sener, Emre; Sener, Goksel
dc.date.accessioned2022-03-12T17:52:41Z
dc.date.available2022-03-12T17:52:41Z
dc.date.issued2011
dc.description.abstractObjectives This study aimed to investigate the antioxidant and anti-inflammatory effects of caffeic acid phenethyl ester (CAPE) on the methotrexate (MTX)-induced hepatorenal oxidative damage in rats. Methods Following a single dose of methotrexate (20 mg/kg), either vehicle (MTX group) or CAPE (10 mu mol/kg, MTX + CAPE group) was administered for five days. In other rats, vehicle (control group) or CAPE was injected for five days, following a single dose of saline injection. After decapitation of the rats, trunk blood was obtained, and the liver and kidney tissues were removed for histological examination and for the measurement of malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) and sodium potassium-adenosine triphosphatase (Na+/K+-ATPase) activity. TNF-alpha and IL-1 beta levels were measured in the blood. Key findings Methotrexate administration increased the tissue MDA levels, MPO activity and decreased GSH levels and Na+/K+-ATPase activity, while these alterations were reversed in the CAPE-treated MTX group. Elevated TNF-alpha and IL-1 beta levels were also reduced with CAPE treatment. Conclusions The results of this study revealed that CAPE, through its anti-inflammatory and antioxidant actions, alleviates methotrexate-induced oxidative damage, which suggests that CAPE may be of therapeutic benefit when used with methotrexate.
dc.identifier.doi10.1111/j.2042-7158.2011.01359.x
dc.identifier.eissn2042-7158
dc.identifier.issn0022-3573
dc.identifier.pubmed22060287
dc.identifier.urihttps://hdl.handle.net/11424/230424
dc.identifier.wosWOS:000297418400008
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF PHARMACY AND PHARMACOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcaffeic acid phenethyl ester
dc.subjectkidney
dc.subjectliver
dc.subjectmethotrexate
dc.subjectoxidative damage
dc.subjectINDUCED NEPHROTOXICITY
dc.subjectLIPID-PEROXIDATION
dc.subjectSTRESS
dc.subjectANTIOXIDANT
dc.subjectKIDNEY
dc.subjectPROPOLIS
dc.subjectCELLS
dc.subjectLIVER
dc.subjectMYELOPEROXIDASE
dc.subjectPHARMACOLOGY
dc.titleCaffeic acid phenethyl ester (CAPE) prevents methotrexate-induced hepatorenal oxidative injury in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id7a41781b-38c6-4a65-a2b5-f15a4ff0cfeb
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages6
oaire.citation.endPage1571
oaire.citation.issue12
oaire.citation.startPage1566
oaire.citation.titleJOURNAL OF PHARMACY AND PHARMACOLOGY
oaire.citation.volume63
relation.isAuthorOfPublicationedcd2255-94d5-4f56-b0c8-1385c55279b0
relation.isAuthorOfPublication.latestForDiscoveryedcd2255-94d5-4f56-b0c8-1385c55279b0

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