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Efficacy of salbutamol and ipratropium bromide in the management of acute bronchiolitis - A clinical trial

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dc.contributor.authorKARADAĞ, BÜLENT TANER
dc.contributor.authorsKaradag, Bulent; Ceran, Omer; Guven, Gulsah; Dursun, Esengul; Ipek, Ilke Ozahi; Karakoc, Fazilet; Ersu, Refika Hamutcu; Bozaykut, Abdulkadir; Inan, Savas; Dagli, Elif
dc.date.accessioned2022-03-12T17:35:07Z
dc.date.available2022-03-12T17:35:07Z
dc.date.issued2008
dc.description.abstractBackground: A wide range of drugs are commonly used to treat bronchiolitis, but evidence of their effectiveness is limited. Objectives: To investigate the efficacy of ipratropium bromide and salbutamol in the treatment of patients with moderate-severe bronchiolitis. Methods: Sixty-nine infants with moderate- severe bronchiolitis hospitalized at their first episode of wheezing or crepitations in the chest were enrolled in a prospective, double-blind, placebo-controlled trial. Patients were randomly assigned to receive nebulized salbutamol, ipratropium bromide or placebo. Main outcome measures were changes in oxygen saturation rates and clinical scores and duration of hospitalization. Results: In the bronchodilator groups, clinical scores were better compared to the placebo group at 30 min ( 8.4 +/- 1.3 vs. 7.5 +/- 0.8, p < 0.05). Bronchodilator groups had also significantly lower clinical scores (7.3 +/- 1.2 vs. 5.9 +/- 1.1, p < 0.0001, and 5.3 +/- 1.4 vs. 4.5 +/- 1.6, p = 0.006, respectively) and higher oxygen saturation rates compared to the placebo group at 8 and 24 h ( 89.6 +/- 2.4 vs. 94.3 +/- 4.4, and 92.2 +/- 2.6 vs. 95.9 +/- 4.4, respectively, p < 0.0001). Improvement rates and duration of hospitalization were not statistically different among groups. Conclusions: Clinical scores and oxygen saturation levels improved more rapidly in the bronchodilator groups than in the placebo group up to 24 h, but these drugs did not have a sufficient effect to change the natural course of the disease. Copyright (C) 2007 S. Karger AG, Basel.
dc.identifier.doi10.1159/000111817
dc.identifier.eissn1423-0356
dc.identifier.issn0025-7931
dc.identifier.pubmed18042975
dc.identifier.urihttps://hdl.handle.net/11424/229119
dc.identifier.wosWOS:000259784600008
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofRESPIRATION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbronchiolitis
dc.subjectbronchodilators
dc.subjectchildren
dc.subjectipratropium bromide
dc.subjectsalbutamol
dc.subjectBRONCHODILATORS
dc.subjectTHERAPY
dc.subjectINFANTS
dc.titleEfficacy of salbutamol and ipratropium bromide in the management of acute bronchiolitis - A clinical trial
dc.typearticle
dspace.entity.typePublication
local.avesis.id299f27cc-1fda-47f7-92cd-27590f42c369
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage287
oaire.citation.issue3
oaire.citation.startPage283
oaire.citation.titleRESPIRATION
oaire.citation.volume76
relation.isAuthorOfPublication218b489d-97ab-49dd-9db6-0c2a732f1999
relation.isAuthorOfPublication.latestForDiscovery218b489d-97ab-49dd-9db6-0c2a732f1999

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