Publication:
Matrix Metalloproteinase-9 Level and Gene Polymorphism in Sleep Disordered Breathing Patients with or without Cardiovascular Disorders

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dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsYuksel, Meral; Kuzu-Okur, Hacer; Velioglu-Ogunc, Ayliz; Pelin, Zerrin
dc.date.accessioned2022-03-14T10:55:57Z
dc.date.available2022-03-14T10:55:57Z
dc.date.issued2013-03-05
dc.description.abstractObjective: Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular morbidity and mortality. We aimed to investigate the matrix metalloproteinase-9 (MMP-9) level and MMP-9 gene polymorphism in sleep apnea patients with or without cardiovascular disease. Study Design: Case-control study. Material and Methods: Two hundred nine patients [Mean age (+/- SD), 47 (+/- 12) yrs; M/F, 170/39] diagnosed with sleep-disordered breathing were included in the study. Serum MMP-9 level was performed using enzyme-linked immunosorbant assay (ELISA) and MMP-9 gene polymorphism with polymerase chain reaction-restriction fragment length polymorphism. We divided the patient group into two subgroups: (1) patients with confirmed cardiovascular disease, i.e. CV-P Group and (2) patients without cardiovascular disease, CV-N Group. We compared all parameters between the two groups. Results: There were 56 OSAS patients with cardiovascular disorder (CV-positive group) and 153 OSAS patients without cardiovascular disorder (CV-negative group). CC, CT and TT genotype distributions between groups were similar [31 (55%), 25 (45%), 0 (0%) vs 88 (57%), 61 (40%), 4 (3%); respectively, p>0.05]. MMP-9 level was significantly higher in CV-P patients (442.7 +/- 139.3 pg/mL) than in CV-N patients (364.4 +/- 165.0 pg/mL; p=0.0018). Conclusion: Our results showed that the presence of MMP-9 polymorphism was not associated with cardiovascular disease. MMP-9 level was higher in OSAS patients with cardiovascular disorders than without cardiovascular disorders. Finally, MMP-9 genotype was not associated with serum MMP-9 levels.
dc.identifier.doi10.5152/balkanmedj.2012.068
dc.identifier.issn2146-3123
dc.identifier.pubmed25207060
dc.identifier.urihttps://hdl.handle.net/11424/245504
dc.identifier.wosWOS:000317543300004
dc.language.isoeng
dc.publisherAVES YAYINCILIK
dc.relation.ispartofBALKAN MEDICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiovascular disease
dc.subjectMMP-9
dc.subjectpolymorphism
dc.subjectsleep apnea
dc.subjecthypertension
dc.subjectCORONARY-ARTERY-DISEASE
dc.subjectFUNCTIONAL POLYMORPHISM
dc.subjectAPNEA SYNDROME
dc.subjectGELATINASE
dc.subjectEXPRESSION
dc.subjectRISK
dc.titleMatrix Metalloproteinase-9 Level and Gene Polymorphism in Sleep Disordered Breathing Patients with or without Cardiovascular Disorders
dc.typearticle
dspace.entity.typePublication
local.avesis.id3420d844-8ea0-47a2-b0fa-b2d34197bd3d
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage12
oaire.citation.issue1
oaire.citation.startPage8
oaire.citation.titleBALKAN MEDICAL JOURNAL
oaire.citation.volume30
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

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