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Healthcare-associated Staphylococcus aureus infections in children in Turkey: A six-year retrospective, single-center study

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dc.contributor.authorSAYIN, ELVAN
dc.contributor.authorİLKİ, ZEYNEP ARZU
dc.contributor.authorKEPENEKLİ KADAYİFCİ, EDA
dc.contributor.authorsYakut N., Ergenc Z., Aslan Tuncay S., Bayraktar S., Sayin E., Ilki Z. A., Kepenekli Kadayifci E.
dc.date.accessioned2023-12-11T08:10:19Z
dc.date.available2023-12-11T08:10:19Z
dc.date.issued2023-08-01
dc.description.abstractObjective: To describe clinical and epidemiological characteristics, antimicrobial susceptibility and mortality-associated factors of healthcare-associated infections (HCAIs) caused by Staphylococcus (S.) aureus in children. Methods: We conducted a retrospective, single-centre study of pediatric HCAIs caused by S. aureus from a tertiary care hospital in Turkey between February 2014 and December 2019. The clinical and epidemiological characteristics and antimicrobial susceptibility of the methicillin-susceptible and methicillin-resistant S. aureus (MSSA and MRSA) isolates was evaluated. Results: A total of 310 pediatric patients were examined. Overall, 225 (72.6%) isolates were MSSA and 85 (27.4%) were MRSA. All S. aureus isolates were susceptible to teicoplanin, vancomycin, linezolid, tigecycline, mupirocin, and daptomycin. Penicillin resistance rates were high (89.0%), while fosfomycin, gentamicin, and clindamycin resistance rates were low (1.3%, 1.0%, and 2.3%, respectively). Except susceptibility to fosfomycin, which was significantly lower in 2014 compared to 2018 and 2019, no significant difference was found in the antimicrobial susceptibility of S. aureus isolates between the years. Baseline characteristics and mortality rate were similar comparing MRSA and MSSA causing HCAIs. The mortality rate of HCAIs caused by S. aureus was 6.5% (20 patients). Malignancy was an independent risk factor associated with mortality in the multivariate analysis (OR 5.446, 95% CI 1.573- 18.849). Conclusions: Our findings demonstrate that MSSA remained the most causative agent of HCAIs caused by S. aureus. The mortality rate was 6.5%, the antibiotic resistance rate was quite high for penicillin and diagnosis of malignancy was the main risk factor for increasing mortality in children. These findings could help improve the management of HCAIs caused by S. aureus in children.
dc.identifier.citationYakut N., Ergenc Z., Aslan Tuncay S., Bayraktar S., Sayin E., Ilki Z. A., Kepenekli Kadayifci E., "Healthcare-associated Staphylococcus aureus infections in children in Turkey: A six-year retrospective, single-center study", ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, cilt.16, sa.8, ss.354-362, 2023
dc.identifier.doi10.4103/1995-7645.380721
dc.identifier.endpage362
dc.identifier.issn1995-7645
dc.identifier.issue8
dc.identifier.startpage354
dc.identifier.urihttps://journals.lww.com/aptm/fulltext/2023/16080/healthcare_associated_staphylococcus_aureus.4.aspx
dc.identifier.urihttps://hdl.handle.net/11424/295505
dc.identifier.volume16
dc.language.isoeng
dc.relation.ispartofASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectMikrobiyoloji ve Klinik Mikrobiyoloji
dc.subjectTıbbi Mikrobiyoloji
dc.subjectDahili Tıp Bilimleri
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectPediatrik Enfeksiyon
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectMicrobiology and Clinical Microbiology
dc.subjectMedical Microbiology
dc.subjectInternal Medicine Sciences
dc.subjectChild Health and Diseases
dc.subjectPediatrics Infectious Diseases
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectMikrobiyoloji
dc.subjectPEDİATRİ
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectMİKROBİYOLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectCLINICAL MEDICINE
dc.subjectMICROBIOLOGY
dc.subjectPEDIATRICS
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectGenel Sağlık Meslekleri
dc.subjectPediatri
dc.subjectPatofizyoloji
dc.subjectTemel Bilgi ve Beceriler
dc.subjectDeğerlendirme ve Teşhis
dc.subjectPediatri, Perinatoloji ve Çocuk Sağlığı
dc.subjectMikrobiyoloji (tıbbi)
dc.subjectDahiliye
dc.subjectAile Sağlığı
dc.subjectTıp (çeşitli)
dc.subjectGenel Tıp
dc.subjectİmmünoloji ve Mikrobiyoloji (çeşitli)
dc.subjectYaşam Bilimleri
dc.subjectGeneral Health Professions
dc.subjectPediatrics
dc.subjectPathophysiology
dc.subjectFundamentals and Skills
dc.subjectAssessment and Diagnosis
dc.subjectPediatrics, Perinatology and Child Health
dc.subjectMicrobiology (medical)
dc.subjectInternal Medicine
dc.subjectFamily Practice
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjectMicrobiology
dc.subjectImmunology and Microbiology (miscellaneous)
dc.subjectLife Sciences
dc.subjectHealthcare-associated infections
dc.subjectStaphylococcus aureus
dc.subjectChildren
dc.subjectAntimicrobial susceptibility
dc.subjectMortality
dc.titleHealthcare-associated Staphylococcus aureus infections in children in Turkey: A six-year retrospective, single-center study
dc.typearticle
dspace.entity.typePublication
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