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Accelerated diabetic wound healing by topical application of combination oral antidiabetic agents-loaded nanofibrous scaffolds: An in vitro and in vivo evaluation study

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dc.contributor.authorYAVUZ, AYŞE NUR
dc.contributor.authorsCam, Muhammet Emin; Ertas, Busra; Alenezi, Hussain; Hazar-Yavuz, Ayse Nur; Cesur, Sumeyye; Ozcan, Gul Sinemcan; Ekentok, Ceyda; Guler, Ece; Katsakouli, Christina; Demirbas, Zehra; Akakin, Dilek; Eroglu, Mehmet Sayip; Kabasakal, Levent; Gunduz, Oguzhan; Edirisinghe, Mohan
dc.date.accessioned2022-03-14T09:56:37Z
dc.date.available2022-03-14T09:56:37Z
dc.date.issued2021-02
dc.description.abstractThe combination of oral antidiabetic drugs, pioglitazone, metformin, and glibenclamide, which also exhibit the strongest anti-inflammatory action among oral antidiabetic drugs, were loaded into chitosan/gelatin/polycaprolactone (PCL) by electrospinning and polyvinyl pyrrolidone (PVP)/PCL composite nanofibrous scaffolds by pressurized gyration to compare the diabetic wound healing effect. The combination therapies significantly accelerated diabetic wound healing in type-1 diabetic rats and organized densely packed collagen fibers in the dermis, it also showed better regeneration of the dermis and epidermis than single drug-loaded scaffolds with less inflammatory cell infiltration and edema. The formation of the hair follicles started in 14 days only in the combination therapy and lower proinflammatory cytokine levels were observed compared to single drug-loaded treatment groups. The combination therapy increased the wettability and hydrophilicity of scaffolds, demonstrated sustained drug release over 14 days, has high tensile strength and suitable cytocompatibility on L929 (mouse fibroblast) cell and created a suitable area for the proliferation of fibroblast cells. Consequently, the application of metformin and pioglitazone-loaded chitosan/gelatin/PCL nanofibrous scaffolds to a diabetic wound area offer high bioavailability, fewer systemic side effects, and reduced frequency of dosage and amount of drug.
dc.identifier.doi10.1016/j.msec.2020.111586
dc.identifier.eissn1873-0191
dc.identifier.issn0928-4931
dc.identifier.pubmed33321632
dc.identifier.urihttps://hdl.handle.net/11424/243729
dc.identifier.wosWOS:000600894100002
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetic wound healing
dc.subjectPioglitazone
dc.subjectMetformin
dc.subjectGlibenclamide
dc.subjectDrug delivery
dc.subjectPressurized gyration
dc.subjectElectrospinning
dc.subjectGELATIN
dc.subjectCHITOSAN
dc.subjectMETFORMIN
dc.subjectHYPERGLYCEMIA
dc.subjectPIOGLITAZONE
dc.subjectFABRICATION
dc.subjectRECEPTOR
dc.subjectDELIVERY
dc.subjectPPAR
dc.subjectGLIBENCLAMIDE
dc.titleAccelerated diabetic wound healing by topical application of combination oral antidiabetic agents-loaded nanofibrous scaffolds: An in vitro and in vivo evaluation study
dc.typearticle
dspace.entity.typePublication
local.avesis.idf6e8424b-a866-4e6a-8bc8-98e3d9447d63
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber111586
local.journal.numberofpages21
oaire.citation.titleMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
oaire.citation.volume119
relation.isAuthorOfPublication0bd18078-950c-4d8c-93f6-120ce419897d
relation.isAuthorOfPublication.latestForDiscovery0bd18078-950c-4d8c-93f6-120ce419897d

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