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Changing clinical characteristics of non-cystic fibrosis bronchiectasis in children

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dc.contributor.authorKARADAĞ, BÜLENT TANER
dc.contributor.authorsEralp, Ela Erdem; Gokdemir, Yasemin; Atag, Emine; Ikizoglu, Nilay Bas; Ergenekon, Pinar; Yegit, Cansu Yilmaz; Kut, Arif; Ersu, Refika; Karakoc, Fazilet; Karadag, Bulent
dc.date.accessioned2022-03-14T10:10:21Z
dc.date.available2022-03-14T10:10:21Z
dc.date.issued2020-12
dc.description.abstractBackground The prevalence of non-cystic fibrosis (CF) bronchiectasis is increasing in both developed and developing countries in recent years. Although the main features remain similar, etiologies seem to change. Our aim was to evaluate the clinical and laboratory characteristics of our recent non-CF bronchiectasis patients and to compare these with our historical cohort in 2001. Methods One hundred four children with non-CF bronchiectasis followed between 2002 and 2019 were enrolled. Age of diagnosis, underlying etiology and microorganisms in sputum culture were recorded. Clinical outcomes were evaluated in terms of lung function tests and annual pulmonary exacerbation rates at presentation and within the last 12 months. Results Mean FEV1 and FVC %predicted at presentation improved compared to historical cohort (76.6 +/- 17.1 vs. 63.3 +/- 22.1 and 76.6 +/- 15.1 vs. 67.3 +/- 23.1, respectively;p < 0.001). There was a significant decrease in pulmonary exacerbation rate from 6.05 +/- 2.88 at presentation to 3.23 +/- 2.08 during follow-up (p < 0.0001). In 80.8% of patients, an underlying etiology was identified. There was an increase in primary ciliary dyskinesia (PCD) (32.7% vs. 6.3%;p = 0.001), decrease in idiopathic cases (19.2% vs. 37.8%;p = 0.03) with no change in postinfectious and immunodeficiencies as underlying etiology. Sputum cultures were positive in 77.9% of patients which was 46.9% in the historical cohort (p = 0.001). Conclusion Baseline pulmonary function tests were better and distribution of underlying etiology had changed with a remarkable increase in diagnosis of PCD in the recent cohort.
dc.identifier.doi10.1186/s12890-020-01214-7
dc.identifier.issn1471-2466
dc.identifier.pubmed32546272
dc.identifier.urihttps://hdl.handle.net/11424/244152
dc.identifier.wosWOS:000542726200002
dc.language.isoeng
dc.publisherBMC
dc.relation.ispartofBMC PULMONARY MEDICINE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBronchiectasis
dc.subjectChild
dc.subjectPrimary ciliary dyskinesia
dc.subjectSpirometry
dc.subjectSUPPURATIVE LUNG-DISEASE
dc.subjectNON-CF BRONCHIECTASIS
dc.subjectETIOLOGY
dc.subjectPOPULATION
dc.subjectPROFILE
dc.titleChanging clinical characteristics of non-cystic fibrosis bronchiectasis in children
dc.typearticle
dspace.entity.typePublication
local.avesis.id69733ecd-9235-4a02-9ad3-81368111e667
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber172
local.journal.numberofpages8
local.journal.quartileQ2
oaire.citation.issue1
oaire.citation.titleBMC PULMONARY MEDICINE
oaire.citation.volume20
relation.isAuthorOfPublication218b489d-97ab-49dd-9db6-0c2a732f1999
relation.isAuthorOfPublication.latestForDiscovery218b489d-97ab-49dd-9db6-0c2a732f1999

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