Publication:
Pulmonary arterial wall thickness is increased in Behçet's disease patients with major organ ınvolvement: Is it a sign of severity?

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dc.contributor.authorKOCAKAYA, DERYA
dc.contributor.authorDİRESKENELİ, RAFİ HANER
dc.contributor.authorALİBAZ ÖNER, FATMA
dc.contributor.authorsAğaçkıran S. K., Sünbül M., Doğan Z., Kocakaya D., Kayacı S., Direskeneli H., Alibaz-Oner F.
dc.date.accessioned2023-08-11T08:12:23Z
dc.date.available2023-08-11T08:12:23Z
dc.date.issued2023-03-01
dc.description.abstractObjectives Behcet\"s disease (BD) is a unique systemic vasculitis mainly involving veins, in contrast to other vasculitides. Prior studies have shown that pulmonary arteries (PAs) have a similar structure to systemic veins. In this study we aimed to assess PA wall thickness by transthoracic echocardiography (TTE) in BD patients compared with healthy controls (HCs) and patients with non-inflammatory pulmonary embolism (NIPE). Methods Patients with BD (n = 77) and NIPE (n = 33) and HCs (n = 57) were studied. PA wall thickness was measured from the mid-portion of the main PA with TTE by two cardiologists blinded to cases. Results PA wall thickness was significantly lower in HCs [3.6 mm (s.d. 0.3)] compared with NIPE [4.4 mm (s.d. 0.5)] and BD [4.4 mm (s.d. 0.6)] (P < 0.001 for both). PA wall thickness was similar between BD and NIPE (P = 0.6). Among patients with BD, PA wall thickness was significantly higher in patients with major organ involvement compared with mucocutaneous limited disease [4.7 mm (s.d. 0.4) vs 3.7 (0.4), P < 0.001], HCs and NIPE (P < 0.001 and P = 0.006, respectively). PA wall thickness was comparable between patients with vascular and non-vascular major organ involvement [4.6 mm (s.d. 0.5) vs 4.7 (0.3), P = 0.3]. Conclusion We observed that PA wall thickness was significantly higher in BD with major organ involvement compared with patients with only mucocutaneous limited disease, HCs and NIPE. These results suggest that increased PA wall thickness may be a sign of severe disease with major organ involvement in BD.
dc.identifier.citationAğaçkıran S. K., Sünbül M., Doğan Z., Kocakaya D., Kayacı S., Direskeneli H., Alibaz-Oner F., "Pulmonary arterial wall thickness is increased in Behçet's disease patients with major organ ınvolvement: Is it a sign of severity?", Rheumatology (Oxford, England), cilt.62, ss.1238-1242, 2023
dc.identifier.doi10.1093/rheumatology/keac452
dc.identifier.endpage1242
dc.identifier.issn1462-0324
dc.identifier.startpage1238
dc.identifier.urihttps://hdl.handle.net/11424/292314
dc.identifier.volume62
dc.language.isoeng
dc.relation.ispartofRheumatology (Oxford, England)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectGöğüs Hastalıkları ve Allerji
dc.subjectİç Hastalıkları
dc.subjectİmmünoloji ve Romatoloji
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectInternal Medicine Sciences
dc.subjectChest Diseases and Allergy
dc.subjectInternal Diseases
dc.subjectImmunology and Rheumatology
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectROMATOLOJİ
dc.subjectSOLUNUM SİSTEMİ
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectRHEUMATOLOGY
dc.subjectRESPIRATORY SYSTEM
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectSolunum Bakımı
dc.subjectGenel Sağlık Meslekleri
dc.subjectPatofizyoloji
dc.subjectTemel Bilgi ve Beceriler
dc.subjectDeğerlendirme ve Teşhis
dc.subjectRomatoloji
dc.subjectAkciğer ve Solunum Tıbbı
dc.subjectDahiliye
dc.subjectAile Sağlığı
dc.subjectTıp (çeşitli)
dc.subjectGenel Tıp
dc.subjectRespiratory Care
dc.subjectGeneral Health Professions
dc.subjectPathophysiology
dc.subjectFundamentals and Skills
dc.subjectAssessment and Diagnosis
dc.subjectRheumatology
dc.subjectPulmonary and Respiratory Medicine
dc.subjectInternal Medicine
dc.subjectFamily Practice
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjectBehcet's disease
dc.subjectpulmonary artery wall thickness
dc.subjectechocardiography
dc.subjectULTRASOUND
dc.titlePulmonary arterial wall thickness is increased in Behçet's disease patients with major organ ınvolvement: Is it a sign of severity?
dc.typearticle
dspace.entity.typePublication
local.avesis.id6cd9767e-39fb-46da-a8c1-8500476256f2
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication2771cdd6-7c3b-45a8-89fe-a429a2950516
relation.isAuthorOfPublication07a34d26-21f3-475d-bd36-152d6c659370
relation.isAuthorOfPublicatione995a136-8c56-4192-bebe-fe522b567ef1
relation.isAuthorOfPublication.latestForDiscovery2771cdd6-7c3b-45a8-89fe-a429a2950516

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