Publication:
Role of melatonin in reducing water avoidance stress-induced degeneration of the liver

Simple item page
dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsContuk, G; Ercan, F; Cetinel, S; Cikler, E; Sener, G
dc.date.accessioned2022-03-12T17:19:02Z
dc.date.available2022-03-12T17:19:02Z
dc.date.issued2005
dc.description.abstractMelatonin, a pineal secretory product, is a potent scavenger of a variety of free radicals. We investigated the role of melatonin on water avoidance stress (WAS)-induced degenerations of the liver parenchyme. Wistar albino rats were exposed to acute WAS (aWAS group) or chronic WAS (cWAS group). Before exposing animals to acute (aWAS + mel group) or chronic WAS (cWAS + mel group), 10 mg/kg melatonin was injected i.p. The liver samples were investigated under light and transmission electron microscope. Malondialdehyde (MDA) and glutathione (GSH) levels were also determined. Prominent vascular congestion and dilated sinusoids, activated Kupffer cells with prominent morphology, dilated granular endoplasmic reticulum membranes, and focal picnotic nuclei were observed in the aWAS group; these morphological changes were severe in the cWAS group. MDA level was increased and GSH level was decreased significantly in the cWAS group. The morphology of liver parenchme in both the aWAS + mel and the cWAS + mel group showed that melatonin significantly reduced the degeneration in liver; besides, a significant decrease in MDA and an increase in GSH levels were observed in the cWAS + mel group. Based on the results, melatonin treatment significantly prevented WAS-induced morphological and biochemical changes in liver parenchyma.
dc.identifier.doi10.1007/s10620-005-2566-0
dc.identifier.eissn1573-2568
dc.identifier.issn0163-2116
dc.identifier.pubmed15844711
dc.identifier.urihttps://hdl.handle.net/11424/228048
dc.identifier.wosWOS:000228205200023
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofDIGESTIVE DISEASES AND SCIENCES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectwater avoidance stress
dc.subjectliver
dc.subjectmorphology
dc.subjectlipid peroxidation
dc.subjectglutathione
dc.subjectmelatonin
dc.subjectLIPID-PEROXIDATION
dc.subjectOXIDATIVE STRESS
dc.subjectRAT
dc.subjectGLUTATHIONE
dc.subjectINJURY
dc.subjectDAMAGE
dc.subjectINFLAMMATION
dc.subjectMECHANISMS
dc.subjectTRANSPORT
dc.subjectCOLON
dc.titleRole of melatonin in reducing water avoidance stress-induced degeneration of the liver
dc.typearticle
dspace.entity.typePublication
local.avesis.idb68ff6f4-4495-46fa-b443-8820251451b5
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage744
oaire.citation.issue4
oaire.citation.startPage738
oaire.citation.titleDIGESTIVE DISEASES AND SCIENCES
oaire.citation.volume50
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

Files

Collections

Research Outputs