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Gentamicin-loaded polyvinyl alcohol/whey protein isolate/hydroxyapatite 3D composite scaffolds with drug delivery capability for bone tissue engineering applications

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorsTut T. A. , Cesur S., Ilhan E., ŞAHİN A., Yildirim O. S. , GÜNDÜZ O.
dc.date.accessioned2022-09-29T11:42:53Z
dc.date.available2022-09-29T11:42:53Z
dc.date.issued2022-10-05
dc.description.abstractBone defects caused by diseases such as bone diseases, tumours, and traumas negatively affect the lives of millions of people around the world. Bone tissue engineering offers a new approach to repairing bone defects. Here, a novel bioactive Polyvinyl alcohol (PVA)/ Whey protein isolate (WPI)/ Hydroxyapatite (HA) composite scaffolds with Gentamicin (GEN)-loaded at varying rates were successfully fabricated by 3D printing technology. The strong interaction between PVA, WPI, HA, and GEN were proved with Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). When the scanning electron microscopy (SEM) images of the produced 3D composite scaffolds were evaluated, it can be said that 3D composite scaffolds with the desired porosity and structure for bone tissue engineering applications were obtained. The 3D PVA/WPI/HA/12GEN composite scaffold was fabricated excellently with its 675 μm pore size. Compression tests revealed that the 3D composite scaffold had a compressive strength of 1.28–1.22 MPa and strain of % 12.89–8.70 and thus met the mechanical desirables of human trabecular bone. Moreover, the compressive strength and strain values of the scaffolds were decreased slightly due to adding the GEN drug. According to the Differential scanning calorimetry (DSC) analysis, it was determined that the highly crystalline structure of PVA was disrupted by adding GEN to the composite scaffolds. It was also observed that the addition of GEN to the scaffold did not significantly affect the swelling and degradation behaviour, and the scaffolds degraded by approximately 55% on the 10th day. The scaffolds exhibited a controlled release profile up to 240 and 264 h and were released with the Korsmeyer-Peppas kinetic model according to the highest correlation number. Cell analysis revealed that biocompatible structures were produced, and osteoblasts formed filopodia extensions, resulting in healthy cell attachment. According to these results, 3D GEN-loaded PVA/WPI/HA composite scaffolds may be a promising innovation for bone defect repair in bone tissue engineering applications.
dc.identifier.citationTut T. A. , Cesur S., Ilhan E., ŞAHİN A., Yildirim O. S. , GÜNDÜZ O., "Gentamicin-loaded polyvinyl alcohol/whey protein isolate/hydroxyapatite 3D composite scaffolds with drug delivery capability for bone tissue engineering applications", European Polymer Journal, cilt.179, 2022
dc.identifier.doi10.1016/j.eurpolymj.2022.111580
dc.identifier.issn0014-3057
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85138106173&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/281951
dc.identifier.volume179
dc.language.isoeng
dc.relation.ispartofEuropean Polymer Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFizik
dc.subjectAstronomi ve Astrofizik
dc.subjectKimya
dc.subjectBiyokimya
dc.subjectBiyoinorganik Kimya
dc.subjectFizikokimya
dc.subjectPolimer Karakterizasyonu
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectPhysics
dc.subjectAstronomy and Astrophysics
dc.subjectChemistry
dc.subjectBiochemistry
dc.subjectBioinorganic Chemistry
dc.subjectPhysical Chemistry
dc.subjectCharacterization of Polymers
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectTemel Bilimler (SCI)
dc.subjectMalzeme Bilimi
dc.subjectUzay bilimi
dc.subjectMALZEME BİLİMİ, MULTIDISCIPLINARY
dc.subjectPOLİMER BİLİMİ
dc.subjectKİMYA, ORGANİK
dc.subjectASTRONOMİ VE ASTROFİZİK
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectNatural Sciences (SCI)
dc.subjectMATERIALS SCIENCE
dc.subjectCHEMISTRY
dc.subjectSPACE SCIENCE
dc.subjectMATERIALS SCIENCE, MULTIDISCIPLINARY
dc.subjectPOLYMER SCIENCE
dc.subjectCHEMISTRY, ORGANIC
dc.subjectASTRONOMY & ASTROPHYSICS
dc.subjectGenel Fizik ve Astronomi
dc.subjectFizik Bilimleri
dc.subjectPolimerler ve Plastikler
dc.subjectOrganik Kimya
dc.subjectMalzeme Kimyası
dc.subjectGeneral Physics and Astronomy
dc.subjectPhysical Sciences
dc.subjectPolymers and Plastics
dc.subjectOrganic Chemistry
dc.subjectMaterials Chemistry
dc.subjectBone tissue engineering
dc.subject3D printing
dc.subjectDrug delivery
dc.subjectGentamicin
dc.subjectWhey protein isolate
dc.subjectHydroxyapatite
dc.subjectPolyvinyl alcohol
dc.titleGentamicin-loaded polyvinyl alcohol/whey protein isolate/hydroxyapatite 3D composite scaffolds with drug delivery capability for bone tissue engineering applications
dc.typearticle
dspace.entity.typePublication
local.avesis.id03cde0b7-0636-4d9e-b9f1-249acfd83aab
local.indexed.atSCOPUS
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relation.isAuthorOfPublicationf11e8073-bf2f-485f-9bdf-5b3a2a0bdc1f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

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