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Light-Processed 3D Bioprinting of Symblepharon Rings Fortified with l-Ascorbic Acid for Ocular Tissue Engineering

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dc.contributor.authorULAĞ, SONGÜL
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorsAyran M., Goyuk Y., Tiryaki A., ULAĞ S., Koyuncu A. C. C., Turhan S. A., GÜNDÜZ O.
dc.date.accessioned2024-06-26T12:55:32Z
dc.date.available2024-06-26T12:55:32Z
dc.date.issued2024-01-01
dc.description.abstractThis study aims to develop gelatin methacryloyl (GelMA)-based symblepharonrings fortified with l-ascorbic acid (lAA), aiming for controlled release ofvitamins for the treatment of the ocular surface, corneal healing, andacceleration of epithelial growth, while concurrently preventing potentialinflammation. The human tears contain abundant IAA, which serves aprotective role for ocular tissues. The utilization of 3D printing digital lightprocessing technology not only navigating the manufacturing process ofsymblepharon rings, addressing challenges related to commercial productionand expedited delivery to patients but also imparts enhanced flexibilitycompared to commercial products. This innovative approach also facilitatesthe production of rings that exhibit superior softness and are amenable tomechanical movements for ocular tissue engineering. The morphological,chemical, rheological, biological, thermal, and drug-release characteristics of3D-printed lAA-loaded symblepharon rings are investigated. In themorphological characterization, it is observed that the rings exhibit a porousstructure. In biocompatibility tests, Gelas and Gelas-low rings achieve over75% viability. Following the cell test, scanning electron microscope imagesreveal fibroblasts adhering to Gelas and Gelas-low rings, spreading acrosstheir surfaces. Drug release studies conducted in phosphate-buffered saline atpH 7.4 reveal the complete release of lAA from Gelas-low within a 5-dincubation period.
dc.identifier.citationAyran M., Goyuk Y., Tiryaki A., ULAĞ S., Koyuncu A. C. C., Turhan S. A., GÜNDÜZ O., "Light-Processed 3D Bioprinting of Symblepharon Rings Fortified with l-Ascorbic Acid for Ocular Tissue Engineering", Macromolecular Materials and Engineering, 2024
dc.identifier.doi10.1002/mame.202400057
dc.identifier.issn1438-7492
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85196203386&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/297095
dc.language.isoeng
dc.relation.ispartofMacromolecular Materials and Engineering
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya Mühendisliği ve Teknolojisi
dc.subjectKimya
dc.subjectBiyokimya
dc.subjectBiyoinorganik Kimya
dc.subjectFizikokimya
dc.subjectPolimer Karakterizasyonu
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectChemical Engineering and Technology
dc.subjectChemistry
dc.subjectBiochemistry
dc.subjectBioinorganic Chemistry
dc.subjectPhysical Chemistry
dc.subjectCharacterization of Polymers
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectTemel Bilimler (SCI)
dc.subjectMühendislik
dc.subjectMalzeme Bilimi
dc.subjectMÜHENDİSLİK, KİMYASAL
dc.subjectPOLİMER BİLİMİ
dc.subjectKİMYA, ORGANİK
dc.subjectMALZEME BİLİMİ, ÇOKDİSİPLİNLİ
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectNatural Sciences (SCI)
dc.subjectENGINEERING
dc.subjectMATERIALS SCIENCE
dc.subjectCHEMISTRY
dc.subjectENGINEERING, CHEMICAL
dc.subjectPOLYMER SCIENCE
dc.subjectCHEMISTRY, ORGANIC
dc.subjectMATERIALS SCIENCE, MULTIDISCIPLINARY
dc.subjectGenel Kimya Mühendisliği
dc.subjectFizik Bilimleri
dc.subjectPolimerler ve Plastikler
dc.subjectOrganik Kimya
dc.subjectMalzeme Kimyası
dc.subjectGeneral Chemical Engineering
dc.subjectPhysical Sciences
dc.subjectPolymers and Plastics
dc.subjectOrganic Chemistry
dc.subjectMaterials Chemistry
dc.subjectDLP printing
dc.subjectGelMA
dc.subjectl-ascorbic acid
dc.subjectsymblepharon rings
dc.titleLight-Processed 3D Bioprinting of Symblepharon Rings Fortified with l-Ascorbic Acid for Ocular Tissue Engineering
dc.typearticle
dspace.entity.typePublication
local.avesis.id068edd49-b9db-4571-9d7a-69d50ee39313
local.indexed.atSCOPUS
relation.isAuthorOfPublication7694c253-e59a-4111-abfb-dcb9eed6d6f8
relation.isAuthorOfPublication88c4b483-9bfd-4c78-8f3b-bab559753b35
relation.isAuthorOfPublication.latestForDiscovery7694c253-e59a-4111-abfb-dcb9eed6d6f8

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