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Gamma knife radiosurgery for cranial neurocytomas

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dc.contributor.authorBOZKURT, SÜHEYLA
dc.contributor.authorsGenc, Ali; Bozkurt, Suheyla Uyar; Karabagli, Pinar; Seker, Askin; Bayri, Yasar; Konya, Deniz; Kilic, Turker
dc.date.accessioned2022-03-12T17:52:05Z
dc.date.available2022-03-12T17:52:05Z
dc.date.issued2011
dc.description.abstractGamma-knife surgery may be an effective alternative for treatment of central neurocytomas owing to its relative safety compared with conventional radiotherapy. In this paper we present results of gamma-knife treatment (GKS) of residual or recurrent neurocytomas. Twenty-two patients (14 female, 8 male) with recurrent or residual neurocytomas who underwent GKS were included. Diagnosis was based on histological findings. The proliferative potential of the tumors was examined by immunostaining with MIB-1 antibody, which is specific for detection of Ki-67 antigen. Tumor volume was determined by using post-gadolinium magnetic resonance images. After GKS treatment, MR imaging was scheduled at three-month intervals in the first year, at six months intervals in the second year, and yearly thereafter. Histopathological diagnoses were: 18 cases of central neurocytomas, two liponeurocytomas, one cerebral neurocytoma and one cerebellar neurocytoma. The MIB1 labeling index (LI) varied from 0 to 5.7%. Marked reduction in tumor volume was seen in 15 patients. In six patients, the tumor volume remained unchanged, and progression was observed for one patient. No complications because of GKS were noted. Shrinking effect on tumor volume increased with increasing duration of follow-up. On the other hand, high MIB labeling index did not seem to have an effect on tumor response to GKS treatment. Findings of this study suggest that GKS is an effective and safe treatment alternative for residual or recurrent neurocytomas. However, its effectiveness should be confirmed with larger studies.
dc.identifier.doi10.1007/s11060-011-0635-0
dc.identifier.eissn1573-7373
dc.identifier.issn0167-594X
dc.identifier.pubmed21732073
dc.identifier.urihttps://hdl.handle.net/11424/230366
dc.identifier.wosWOS:000297803100022
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofJOURNAL OF NEURO-ONCOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCentral neurocytoma
dc.subjectGamma-knife surgery
dc.subjectMIB-1 labeling index
dc.subjectLiponeurocytoma
dc.subjectSTEREOTACTIC RADIOSURGERY
dc.subjectINTRAVENTRICULAR NEUROCYTOMA
dc.subjectCEREBELLAR LIPONEUROCYTOMA
dc.subjectCEREBRAL NEUROCYTOMA
dc.subjectFEATURES
dc.subjectRADIOTHERAPY
dc.subjectSUBGROUPS
dc.subjectSURGERY
dc.subjectTUMORS
dc.titleGamma knife radiosurgery for cranial neurocytomas
dc.typearticle
dspace.entity.typePublication
local.avesis.idb8ffaf44-a550-4479-a3f5-0fbfdfd54d10
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages11
oaire.citation.endPage657
oaire.citation.issue3
oaire.citation.startPage647
oaire.citation.titleJOURNAL OF NEURO-ONCOLOGY
oaire.citation.volume105
relation.isAuthorOfPublicationdd039cf9-dfb8-4af0-b879-0b88c3a852fa
relation.isAuthorOfPublication.latestForDiscoverydd039cf9-dfb8-4af0-b879-0b88c3a852fa

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