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GABA(A) receptor mediated transmission in the thalamic reticular nucleus of rats with genetic absence epilepsy shows regional differences: Functional implications

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsAker, Rezzan Gulhan; Ozyurt, Hazan B.; Yananli, Hasan R.; Cakmak, Yusuf Ozgur; Ozkaynakci, Aydan E.; Sehirli, Umit; Saka, Erdinc; Cavdar, Safiye; Onat, Filiz Yimaz
dc.date.accessioned2022-03-12T17:18:47Z
dc.date.available2022-03-12T17:18:47Z
dc.date.issued2006
dc.description.abstractThe aim of the present study was to investigate the effect of local injections of the GABA(A) receptor antagonist, bicuculline, into the rostral and caudal parts of the thalamic reticular nucleus (TRN), on the generation of spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Spike-and-wave discharges are important in the pathophysiology of absence epilepsy and generated by the cortico-thalamo-cortical pathway, where GABA has a significant role, particularly in the TRN. Artificial cerebrospinal fluid or bicuculline was administered to rostral or caudal parts of TRN of GAERS through a stereotaxically placed guide cannula. Administration of bicuculline produced opposite effects according to the injection site. Administration into the caudal TRN produced statistically significant increases in the duration of spike-and-wave discharges, whereas injections into the rostral TRN produced significant decreases. Correspondingly, distinct patterns of afferent connections have been demonstrated with the wheat-germ-agglutinin horseradish peroxidase (WGA-HRP) retrograde tracing method in control non-epileptic rats and GAERS for the rostral and caudal parts of the TRN. Injection of WGA-HRP tracer showed no detectable difference regarding the rostral and caudal connections between GAERS and Wistar animals. Rostral parts of TRN have thalamic and cortical connections that are primarily motor and limbic whereas for the caudal parts these connections are primarily sensory. Further, the rostral parts receive inputs from the substantia nigra pars reticularis and the ventral pallidum that the caudal part lacks. The extent to which these connectional differences may be responsible for the functional differences demonstrated by the bicucculine injections remains to be explored. (c) 2006 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.brainres.2006.06.118
dc.identifier.issn0006-8993
dc.identifier.pubmed16919245
dc.identifier.urihttps://hdl.handle.net/11424/228011
dc.identifier.wosWOS:000240905200026
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofBRAIN RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbicuculline
dc.subjectGAERS
dc.subjectthalamo-cortical connection
dc.subjectrostral TRN
dc.subjectcaudal TRN
dc.subjectLIMBIC MOTOR SEIZURES
dc.subjectHORSERADISH-PEROXIDASE
dc.subjectWAVE DISCHARGES
dc.subjectWAG/RIJ RATS
dc.subjectIN-VITRO
dc.subjectNEURONS
dc.subjectORGANIZATION
dc.subjectNETWORKS
dc.subjectMODEL
dc.subjectSPIKE
dc.titleGABA(A) receptor mediated transmission in the thalamic reticular nucleus of rats with genetic absence epilepsy shows regional differences: Functional implications
dc.typearticle
dspace.entity.typePublication
local.avesis.ide808c5ee-432b-4d11-973a-0e8012d3695b
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.endPage221
oaire.citation.startPage213
oaire.citation.titleBRAIN RESEARCH
oaire.citation.volume1111
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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