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Fabrication and in vitro characterization of polycaprolactone/graphene oxide/collagen nanofibers for myocardial repair

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dc.contributor.authorULAĞ, SONGÜL
dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorDUMLUDAĞ, FATİH
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorsKarapehlivan S. S., Danisik M. N., Akdag Z., Yildiz E. N., Okoro O. V., Nie L., Shavandi A., ULAĞ S., ŞAHİN A., DUMLUDAĞ F., et al.
dc.date.accessioned2023-12-11T08:23:21Z
dc.date.available2023-12-11T08:23:21Z
dc.date.issued2023-01-01
dc.description.abstractThis study is focused on fabricating tissue-engineered electrospun nanofibers that contain polycaprolactone (PCL), graphene oxide (GO), and collagen (COL) to get an alternative treatment for cardiac injuries. GO (1.5 wt%) is used to support the contraction-elongation of cardiomyocytes by improving electrical stimulation. The COL (1, 3, and 5 wt%) is the main component of the myocardial extracellular matrix have led to their frequent use in cardiac tissue engineering (CTE). The scanning electron microscope (SEM) images show the homogeneous and bead-free morphologies of the nanofibers. Adding a high amount (3% and 5%) of COL decreases the tensile strength value of 17% PCL/1.5% GO nanofiber. 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay demonstrates that the COL addition increases cell viability compared to that in 17% PCL/1.5% GO nanofibers on the third day. The response of the nanofibers to alternating current (AC) signal is studied between the frequencies 40 and 105 Hz. The direct current (DC) conductivity values of the films are determined to be between 1.10−10 and 6.10−10 S m−1 at 25 °C. The AC conductivity values show frequency-dependent behavior. Among the PCL/GO-based electrospun nanofibers, 17% PCL/1.5% GO/5% COL nanofiber shows greater DC and AC conductivity than 17% PCL/1.5% GO nanofiber.
dc.identifier.citationKarapehlivan S. S., Danisik M. N., Akdag Z., Yildiz E. N., Okoro O. V., Nie L., Shavandi A., ULAĞ S., ŞAHİN A., DUMLUDAĞ F., et al., "Fabrication and In Vitro Characterization of Polycaprolactone/Graphene Oxide/Collagen Nanofibers for Myocardial Repair", Macromolecular Materials and Engineering, 2023
dc.identifier.doi10.1002/mame.202300189
dc.identifier.issn1438-7492
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85178411707&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/295511
dc.language.isoeng
dc.relation.ispartofMacromolecular Materials and Engineering
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya Mühendisliği ve Teknolojisi
dc.subjectKimya
dc.subjectBiyokimya
dc.subjectBiyoinorganik Kimya
dc.subjectFizikokimya
dc.subjectPolimer Karakterizasyonu
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectChemical Engineering and Technology
dc.subjectChemistry
dc.subjectBiochemistry
dc.subjectBioinorganic Chemistry
dc.subjectPhysical Chemistry
dc.subjectCharacterization of Polymers
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectTemel Bilimler (SCI)
dc.subjectMühendislik
dc.subjectMalzeme Bilimi
dc.subjectMÜHENDİSLİK, KİMYASAL
dc.subjectPOLİMER BİLİMİ
dc.subjectKİMYA, ORGANİK
dc.subjectMALZEME BİLİMİ, ÇOKDİSİPLİNLİ
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectNatural Sciences (SCI)
dc.subjectENGINEERING
dc.subjectMATERIALS SCIENCE
dc.subjectCHEMISTRY
dc.subjectENGINEERING, CHEMICAL
dc.subjectPOLYMER SCIENCE
dc.subjectCHEMISTRY, ORGANIC
dc.subjectMATERIALS SCIENCE, MULTIDISCIPLINARY
dc.subjectGenel Kimya Mühendisliği
dc.subjectFizik Bilimleri
dc.subjectPolimerler ve Plastikler
dc.subjectOrganik Kimya
dc.subjectMalzeme Kimyası
dc.subjectGeneral Chemical Engineering
dc.subjectPhysical Sciences
dc.subjectPolymers and Plastics
dc.subjectOrganic Chemistry
dc.subjectMaterials Chemistry
dc.subjectcollagen
dc.subjectconductivity
dc.subjectelectrospinning
dc.subjectgraphene oxide
dc.subjectmyocardial tissue
dc.subjectnanofiber
dc.subjectpolycaprolactone
dc.titleFabrication and in vitro characterization of polycaprolactone/graphene oxide/collagen nanofibers for myocardial repair
dc.typearticle
dspace.entity.typePublication
local.avesis.id823544e2-c334-43a8-902d-24c45a35e533
local.indexed.atSCOPUS
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relation.isAuthorOfPublication.latestForDiscovery7694c253-e59a-4111-abfb-dcb9eed6d6f8

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