Publication:
Effects of Ozone on Injury after Gamma Knife Radiosurgery

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dc.contributor.authorÜNAL YILDIRIM, SEMRA
dc.contributor.authorsEmon, Selin Tural; Unal, Semra; Arslanhan, Ayca; Bozkurt, Suheyla Uyar; Meric, Zeynep Cingu; Ziyal, Ibrahim
dc.date.accessioned2022-03-12T22:57:17Z
dc.date.available2022-03-12T22:57:17Z
dc.date.issued2021
dc.description.abstractBACKGROUND: At present, gamma knife radiosurgery plays an important role in neurosurgical procedures. Gamma knife radiosurgery has been used to treat many types of brain tumors and as a functional intervention. However, gamma knife treatment has a devastating effect on the normal brain parenchyma surrounding the target point. It causes increased vascular permeability, vasodilation, and swelling in endothelial cells. Ozone has antioxidant, antiapoptotic, and anti-inflammatory effects in the body. Thus, we evaluated the radioprotective effects of ozone in rats undergoing gamma knife radiation. METHODS: In the present study, 24 Sprague-Dawley male rats weighing 250-300 g in 3 groups of 8 rats each were used. The rats were selected randomly. The control group did not receive any gamma knife radiation. The other 2 groups received 50 Gy of radiation, with 1 group given ozone treatment and the other group not given ozone treatment after gamma knife radiosurgery. At 12 weeks after gamma knife radiation, the rats were sacrificed with high-dose anesthetic agents and the tissues prepared for evaluation. The slides were evaluated for necrosis, vacuolization, glial proliferation, and vascular proliferation using hematoxylin-eosin staining. Vascular endothelial growth factor (VEGF) and extracellular matrix metalloproteinase inducer (also known as CD147) were evaluated using immunohistochemical staining. RESULTS: VEGF expression in glial tissue was significantly less in the group receiving ozone (chi(2) = 15.00; df = 4; P = 0.005) compared with the group that had not received ozone and was similar to the expression in the control group. CONCLUSIONS: The lower expression of VEGF in the group receiving ozone might cause less edema in the surrounding tissue owing to less degradation of vascular permeability in the rat brain tissue.
dc.identifier.doi10.1016/j.wneu.2021.01.061
dc.identifier.eissn1878-8769
dc.identifier.issn1878-8750
dc.identifier.pubmed33508487
dc.identifier.urihttps://hdl.handle.net/11424/237018
dc.identifier.wosWOS:000645619300033
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofWORLD NEUROSURGERY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGamma knife radiosurgery
dc.subjectOzone
dc.subjectRadioprotective
dc.subjectRat
dc.subjectNORMAL RAT-BRAIN
dc.subjectENDOTHELIAL GROWTH-FACTOR
dc.subjectRADIATION NECROSIS
dc.subjectEXPRESSION
dc.subjectSTRESS
dc.subjectDAMAGE
dc.titleEffects of Ozone on Injury after Gamma Knife Radiosurgery
dc.typearticle
dspace.entity.typePublication
local.avesis.id46e4de65-31fc-4962-9961-3fb6f31d834b
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPageE988
oaire.citation.startPageE982
oaire.citation.titleWORLD NEUROSURGERY
oaire.citation.volume149
relation.isAuthorOfPublication58e004a6-536f-4997-ac76-8f097aaa1cea
relation.isAuthorOfPublication.latestForDiscovery58e004a6-536f-4997-ac76-8f097aaa1cea

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