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Neuropeptide W Exhibits Preventive and Therapeutic Effects on Acetic Acid-Induced Colitis via Modulation of the Cyclooxygenase Enzyme System

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dc.contributor.authorARABACI TAMER, SEVİL
dc.contributor.authorERCAN, FERİHA
dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsARABACI TAMER S., Akbulut S., Erdogan O., Cevik O., ERCAN F., YEGEN B.
dc.date.accessioned2023-02-13T07:48:19Z
dc.date.available2023-02-13T07:48:19Z
dc.date.issued2023-01-01
dc.description.abstractBackground The novel peptide neuropeptide W (NPW) was originally shown to function in the control of feeding behavior and energy homeostasis. The aim of this study was to elucidate the putative preventive and therapeutic effects of NPW on colitis-associated oxidative injury and the underlying mechanisms for its action.Methods Sprague-Dawley rats in the acute colitis groups received NPW (0.5, 1 or 5 mu g/kg/day) injections prior to induction of colitis with acetic acid, while the chronic colitis groups were treated after the induction of colitis. In both acute and chronic colitis (CC) groups, treatments were continued for 5 days and the rats were decapitated at the 24th hour of the last injections and colon tissues were collected for assessments.Results NPW pretreatment given for 5 days before colitis induction, as well as treating rats with NPW during the 5-day course of CC, abolished colonic lipid peroxidation. NPW treatment prevented colitis-induced reduction in blood flow, diminished neutrophil infiltration, and pro-inflammatory cytokine responses. NPW pretreatment only at the higher dose reduced colonic edema and microscopic score and preserved colonic glutathione stores. Elevations in cyclooxygenase (COX) enzyme activity and COX-1 protein level during the acute phase of colitis as well as reduction in COX-2 were all reversed with NPW pretreatment. In contrast, NPW treatment was effective in reducing the elevated COX-2 concentration during the chronic phase.Conclusions NPW alleviates acetic acid-induced oxidative colonic injury in rats through the upregulation of colonic blood flow as well as the inhibition of COX-2 protein expression and pro-inflammatory cytokine production.
dc.identifier.citationARABACI TAMER S., Akbulut S., Erdogan O., Cevik O., ERCAN F., YEGEN B., "Neuropeptide W Exhibits Preventive and Therapeutic Effects on Acetic Acid-Induced Colitis via Modulation of the Cyclooxygenase Enzyme System", DIGESTIVE DISEASES AND SCIENCES, 2023
dc.identifier.doi10.1007/s10620-022-07811-2
dc.identifier.issn0163-2116
dc.identifier.urihttps://hdl.handle.net/11424/286100
dc.language.isoeng
dc.relation.ispartofDIGESTIVE DISEASES AND SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectGastroenteroloji-(Hepatoloji)
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectGastroenterology and Hepatology
dc.subjectHealth Sciences
dc.subjectGASTROENTEROLOJİ VE HEPATOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectGASTROENTEROLOGY & HEPATOLOGY
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectHepatoloji
dc.subjectGastroenteroloji
dc.subjectHepatology
dc.subjectGastroenterology
dc.subjectNeuropeptide W
dc.subjectUlcerative colitis
dc.subjectOxidative injury
dc.subjectInflammation
dc.subjectCyclooxygenases
dc.subjectINFLAMMATORY-BOWEL-DISEASE
dc.subjectNITRIC-OXIDE SYNTHASE
dc.subjectULCERATIVE-COLITIS
dc.subjectCROHNS-DISEASE
dc.subjectBLOOD-FLOW
dc.subjectRATS
dc.subjectEXPRESSION
dc.subjectSTRESS
dc.subjectCELLS
dc.subjectPATHOGENESIS
dc.titleNeuropeptide W Exhibits Preventive and Therapeutic Effects on Acetic Acid-Induced Colitis via Modulation of the Cyclooxygenase Enzyme System
dc.typearticle
dspace.entity.typePublication
local.avesis.idd3f51d35-8707-4e83-b97a-5c6bb14741b0
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication6cf6597c-7986-4621-b28a-9e4d7bc35803
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscovery6cf6597c-7986-4621-b28a-9e4d7bc35803

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