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Nitric oxide and endothelin relationship in intestinal ischemia/reperfusion injury (II)

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dc.contributor.authorDAĞLI, EMRULLAH TOLGA
dc.contributor.authorsOzel, SK; Yuksel, M; Haklar, G; Durakbasa, CU; Dagli, TE; Aktan, AO
dc.date.accessioned2022-03-12T17:01:17Z
dc.date.available2022-03-12T17:01:17Z
dc.date.issued2001
dc.description.abstractEndothelins (ETs) are potent vasoconstrictors derived from vascular endothelium. They have primary roles in many pathophysiologic states including ischemia/reperfusion (I/R) injury. The relationships between nitric oxide (NO) and ETs are still under investigation. In this study on rats we want to focus on the interaction of NO and ET especially in I/R injury. For this purpose ET-1 and PD-156252, a nonselective ET receptor blocker, were given in a mesenteric I/R model and reactive oxygen species were detected directly using chemiluminescence of the ileal tissue. ET administrations to sham and I/R groups caused significant increases in NO concentrations whereas, in terms of peroxynitrite, which is a highly reactive group of free radicals, its increasing effects were seen only in I/R groups. This suggests that in I/R where superoxide levels increase together with NO, the conversion to peroxynitrite is likely and this effect is augmented with ET administration. On the other hand PD administration decreases superoxide and thereby peroxynitrite levels and this study shows that the effect of PD-156252 is established through this mode of action. These data suggest therapeutic approaches that may be beneficial in the treatment of I/R injury. (C) 2001 Harcourt Publishers Ltd.
dc.identifier.doi10.1054/plef.2001.0268
dc.identifier.issn0952-3278
dc.identifier.pubmed11418020
dc.identifier.urihttps://hdl.handle.net/11424/227367
dc.identifier.wosWOS:000169744700007
dc.language.isoeng
dc.publisherCHURCHILL LIVINGSTONE
dc.relation.ispartofPROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMESENTERIC ISCHEMIA-REPERFUSION
dc.subjectOXYGEN RADICALS
dc.titleNitric oxide and endothelin relationship in intestinal ischemia/reperfusion injury (II)
dc.typearticle
dspace.entity.typePublication
local.avesis.iddd745091-d207-40c0-80b3-6d59da69e5b6
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage257
oaire.citation.issue4-5
oaire.citation.startPage253
oaire.citation.titlePROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
oaire.citation.volume64
relation.isAuthorOfPublicationc7f9c4a9-8b86-46b2-aefe-03541e0f7f7c
relation.isAuthorOfPublication.latestForDiscoveryc7f9c4a9-8b86-46b2-aefe-03541e0f7f7c

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