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Synthesis and cytotoxicity analysis of porous beta-TCP/starch bioceramics

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorsTuran Y., Kalkandelen C., PALACI Y., ŞAHİN A., Gökçe H., GÜNDÜZ O., Ben-Nissan B.
dc.date.accessioned2023-02-16T08:56:15Z
dc.date.available2023-02-16T08:56:15Z
dc.date.issued2022-04-01
dc.description.abstractThe production of porous ceramics for biomedical applications is widely available in the Ceramics industry. In bioceramic applications, interconnected pores are pertinent to increase osteoconductivity and cell proliferation. However, an increase in pore size and the pore amount decrease the mechanical properties. For this reason, pore properties must be precisely controlled. In this study, the effect of a natural pore-forming agent, corn starch addition, and sintering conditions on mechanical properties and biocompatibility was investigated. During mixing, four different starch amounts (1, 3, 5, and 10 wt%) were added to pure beta-tricalcium phosphate (beta-TCP) ceramic powders and pressed. Pressed pellets were sintered at 1000, 1100, 1200, and 1300 degrees C. A scanning electron microscope (SEM) is used to investigate microstructure, texture, pore size, and cell adhesion. The mechanical properties of the beta-TCP ceramic parts were further characterized by measuring the density and compressive strength. Cytotoxicity tests were carried out with MTT assays. The optimum mechanical properties were obtained at 1100 degrees C sintered biocomposites. Although starch starts to burn around 410 degrees C and analytical results show no presence of starch after the sintering process, biocomposites initially containing 10% starch showed improved cell proliferation. However, a reduction of 59% in compressive strength and a 16% reduction in the density were also recorded. It was observed that 10 wt% starch addition increases cell proliferation by 10% in sintered beta-TCP samples. Starch powder additions can be used to increase the cell viability of the material by facilitating the creation of pores, as a low-cost pore-forming agent for porous bone graft and non-load-bearing material in both orthopaedics and maxillofacial applications.
dc.identifier.citationTuran Y., Kalkandelen C., PALACI Y., ŞAHİN A., Gökçe H., GÜNDÜZ O., Ben-Nissan B., "Synthesis and cytotoxicity analysis of porous beta-TCP/starch bioceramics", JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY, cilt.58, sa.2, ss.487-494, 2022
dc.identifier.doi10.1007/s41779-022-00702-9
dc.identifier.endpage494
dc.identifier.issn2510-1560
dc.identifier.issue2
dc.identifier.startpage487
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85124253652&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/286445
dc.identifier.volume58
dc.language.isoeng
dc.relation.ispartofJOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMühendislik ve Teknoloji
dc.subjectEngineering and Technology
dc.subjectMALZEME BİLİMİ, SERAMİK
dc.subjectMalzeme Bilimi
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectMATERIALS SCIENCE, CERAMICS
dc.subjectMATERIALS SCIENCE
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectGeneral Materials Science
dc.subjectCeramics and Composites
dc.subjectPhysical Sciences
dc.subjectbeta-Tricalcium phosphate
dc.subjectPorous bioceramic
dc.subjectalpha-Tricalcium phosphate
dc.subjectStarch
dc.subjectBiocompatibility
dc.subjectTRICALCIUM PHOSPHATE
dc.subjectCALCIUM-PHOSPHATE
dc.subjectHYDROXYAPATITE
dc.subjectSTARCH
dc.subjectWHITLOCKITE
dc.subjectSTABILITY
dc.subjectCERAMICS
dc.subjectCRYSTAL
dc.subjectα-Tricalcium phosphate
dc.subjectβ-Tricalcium phosphate
dc.titleSynthesis and cytotoxicity analysis of porous beta-TCP/starch bioceramics
dc.typearticle
dspace.entity.typePublication
local.avesis.idee57240f-b1dd-47aa-a8cb-2bf276fc1d58
local.indexed.atWOS
local.indexed.atSCOPUS
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relation.isAuthorOfPublicationf11e8073-bf2f-485f-9bdf-5b3a2a0bdc1f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

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