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Synthesis and antituberculosis activity of new N-phenyl-N'-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thioureas

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dc.contributor.authorKARAKUŞ, SEVGİ
dc.contributor.authorsKarakuş, S.; Rollas, S.
dc.date.accessioned2022-03-15T11:22:46Z
dc.date.available2022-03-15T11:22:46Z
dc.date.issued2002
dc.description.abstractIn this study, eight original N-phenyl-N'-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thiourea derivatives were synthesized and tested for antituberculosis activity. Antituberculosis activities of the synthesized compounds were screened in vitro using BACTEC 460 Radiometric System against Mycobacterium tuberculosis H37Rv at 6.25 microg/ml. The highest inhibition observed with the synthesized compounds is 67% for N-phenyl-N'-[4-(5-cyclohexylamino-1,3,4-thiadiazole-2-yl)phenyl]thiourea.
dc.identifier.doi10.1016/s0014-827x(02)01252-1
dc.identifier.issn0014-827X
dc.identifier.pubmedPMID: 12164218
dc.identifier.urihttps://hdl.handle.net/11424/249838
dc.language.isoeng
dc.relation.ispartofFarmaco (Societa Chimica Italiana: 1989)
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMicrobial Sensitivity Tests
dc.subjectAntitubercular Agents
dc.subjectMolecular Structure
dc.subjectDrug Resistance, Microbial
dc.subjectStructure-Activity Relationship
dc.subjectThiourea
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectMycobacterium tuberculosis
dc.titleSynthesis and antituberculosis activity of new N-phenyl-N'-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thioureas
dc.typearticle
dspace.entity.typePublication
local.avesis.iddc0d978e-7f8d-46a6-8de6-95c0669dce9f
local.import.packageSS23
local.import.sourcePubMed
local.indexed.atPUBMED
oaire.citation.endPage581
oaire.citation.startPage577
oaire.citation.titleFarmaco (Societa Chimica Italiana: 1989)
oaire.citation.volume7
relation.isAuthorOfPublicationc93b8083-3f67-4147-bd81-8587eaba18ad
relation.isAuthorOfPublication.latestForDiscoveryc93b8083-3f67-4147-bd81-8587eaba18ad

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