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Production, characterization, and antioxidant activity evaluation of Rheum Ribes L. extract-loaded PLA/PEG nanofibers

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dc.contributor.authorAYAZ SEYHAN, SERAP
dc.contributor.authorBİLĞİÇ ALKAYA, DİLEK
dc.contributor.authorsAYAZ SEYHAN S., Demirel A. B., Cesur S., BİLĞİÇ ALKAYA D.
dc.date.accessioned2023-02-20T11:15:46Z
dc.date.available2023-02-20T11:15:46Z
dc.date.issued2023-01-01
dc.description.abstract© 2023 Marmara University Press.The use of natural compounds such as biocompatible and non-toxic plant extracts, without undesired side effects, in tissue engineering applications, is highly preferred compared to chemical drugs. In recent years, many studies have been carried out to produce nanofibrous materials produced by electrospinning of bioactive plant extracts. Electrospun nanofibers have very large surface area, controllable pore size, and tunable drug release profiles. Several biocompatible polymers with excellent biocompatibility and biodegradability including poly ethylene glycol (PEG) and poly-lactic acid (PLA) have been widely used for the synthesis of nanofibers using the electrospun technique. The ethanol-water extract of the root parts of the Rheum ribes L. plant has antioxidant, antimicrobial, and antiurease effects. In this study, the characterization and performance of electrospun Rheum ribes L.-loaded (20 mg, 40 mg, and 60 mg in 20mL) poly (lactic acid) (PLA) (8%, w/v) /Polyethylene glycol (PEG) (1%, w/v) /Tween 80 (3%, w/v) nanofibrous mats for skin tissue engineering were investigated. Morphological (SEM), molecular interaction (FT-IR), thermal analysis (DSC), antioxidant activity and physical analysis were carried out after the production process. According to the results obtained, Rheum ribes L.-loaded PLA/PEG nanofibers have smooth fiber morphology in fine structure without beads, proper tensile strength and antioxidant activity. Consequently, Rheum ribes L.-loaded nanofibrous mats are suitable for skin tissue engineering applications.
dc.identifier.citationAYAZ SEYHAN S., Demirel A. B., Cesur S., BİLĞİÇ ALKAYA D., "Production, characterization, and antioxidant activity evaluation of Rheum Ribes L. extract-loaded PLA/PEG nanofibers", Journal of Research in Pharmacy, cilt.27, sa.1, ss.146-156, 2023
dc.identifier.doi10.29228/jrp.299
dc.identifier.endpage156
dc.identifier.issn2630-6344
dc.identifier.issue1
dc.identifier.startpage146
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/a890d9cc-71e7-4ddf-aae7-8c0f70bf505f/file
dc.identifier.urihttps://hdl.handle.net/11424/286602
dc.identifier.volume27
dc.language.isoeng
dc.relation.ispartofJournal of Research in Pharmacy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTemel Eczacılık Bilimleri
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectBasic Pharmaceutics Sciences
dc.subjectPharmacology and Therapeutics
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectLife Sciences (LIFE)
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology (medical)
dc.subjectantioxidant activity
dc.subjectElectrospinning
dc.subjectnanofibers
dc.subjectpolylactic acid
dc.subjectrheum ribes L
dc.subjecttissue engineering
dc.titleProduction, characterization, and antioxidant activity evaluation of Rheum Ribes L. extract-loaded PLA/PEG nanofibers
dc.typearticle
dspace.entity.typePublication
local.avesis.ida890d9cc-71e7-4ddf-aae7-8c0f70bf505f
local.indexed.atSCOPUS
relation.isAuthorOfPublication718255e1-6de8-47ba-8bfd-6a8c55a04479
relation.isAuthorOfPublicationb3f0ae46-715d-4b45-bf08-49abdc4adbf4
relation.isAuthorOfPublication.latestForDiscovery718255e1-6de8-47ba-8bfd-6a8c55a04479

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