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Melatonin improves oxidative organ damage in a rat model of thermal injury

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsSener, Göksel; Sehirli, A. Ozer; Satiroğlu, Handan; Keyer-Uysal, Meral; Yeğen, Berrak C.
dc.date.accessioned2022-03-15T11:24:44Z
dc.date.available2022-03-15T11:24:44Z
dc.date.issued2002
dc.description.abstractAnimal models of burn injury indicate oxygen radicals as causative agents in the local wound response, as well as in the development of burn shock and distant organ injury. This study was designed to determine the possible protective effect of melatonin treatment against oxidative damage in the liver, lung and intestine induced by burn injury. Under ether anaesthesia, the shaved dorsum of rats was exposed to a 90 degrees C bath for 10s to induce burn injury. Rats were decapitated either 3 or 24h after burn injury. Melatonin was administered i.p. immediately after burn injury. In the 24h burn group, melatonin injections were repeated for two more occasions. In the sham group the same protocol was applied except that the dorsum was dipped in a 25 degrees C water bath for 10s. Liver, lung and intestine tissues were taken for the determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity and protein oxidation (PO). Severe skin scald injury (30% of total body surface area) caused a significant decrease in GSH level, significant increases in MDA and PO levels, and MPO activity at postburn 3 and 24h. Treatment of rats with melatonin (10mg/kg) significantly elevated the reduced GSH levels while it decreased MDA and PO levels as well as MPO activity.
dc.identifier.doi10.1016/s0305-4179(02)00053-0
dc.identifier.issn0305-4179
dc.identifier.pubmedPMID: 12163279
dc.identifier.urihttps://hdl.handle.net/11424/250172
dc.language.isoeng
dc.relation.ispartofBurns: Journal of the International Society for Burn Injuries
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFemale
dc.subjectAnimals
dc.subjectMale
dc.subjectRats
dc.subjectDisease Models, Animal
dc.subjectMelatonin
dc.subjectRats, Wistar
dc.subjectTime Factors
dc.subjectOxidative Stress
dc.subjectLiver
dc.subjectFree Radical Scavengers
dc.subjectIntestinal Mucosa
dc.subjectBurns
dc.subjectLung
dc.subjectIntestines
dc.subjectLung Injury
dc.titleMelatonin improves oxidative organ damage in a rat model of thermal injury
dc.typearticle
dspace.entity.typePublication
local.avesis.id375246b6-c9b6-4e9d-aefe-37d78bd22766
local.import.packageSS23
local.import.sourcePubMed
local.indexed.atPUBMED
oaire.citation.endPage425
oaire.citation.startPage419
oaire.citation.titleBurns: Journal of the International Society for Burn Injuries
oaire.citation.volume5
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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