Publication:
Consistent intrafamilial transmission of actinobacillus actinomycetemcomitans despite clonal diversity

dc.contributor.authorDOĞAN, BAŞAK
dc.contributor.authorsDogan, Basak; Kipalev, Arzu Sahan; Okte, Emel; Sultan, Nedim; Asikainen, Sirkka E.
dc.date.accessioned2022-03-12T17:35:11Z
dc.date.available2022-03-12T17:35:11Z
dc.date.issued2008
dc.description.abstractBackground: Actinobacillus actinomycetemcomitans is a major pathogen in aggressive periodontitis. Our objectives were to determine the periodontal status and occurrence of A. actinomycetemcomitans in family members of subjects with A. actinomycetemcomitans-positive aggressive periodontitis (AgP) and to evaluate the probability of its intrafamilial transmission. Methods: Of the 300 subjects screened, 66 (22%) had AgP and A. actinomycetemcomitans. Eleven (probands) of these 66 subjects with AgP met the strict inclusion criteria for the study. The study population consisted of 55 subjects, including probands and their family members (N = 44). Two family groups were formed according to whether the proband was a child (N = 7) or a parent (N = 4). Subgingival samples from all subjects were cultured for A. actinomycetemcomitans, and its clonal types were determined by combining serotype and genotype data for each isolate. Results: Among 42 dentate family members, 16 (38%) exhibited periodontitis and eight (50%) had AgP. Periodontitis was found in nine of 12 (75%) of the dentate parents and six of 17 (35%) siblings of the child probands. A. actinomycetemcomitans was detected in 16 of 31 (52%) family members, i.e., one parent and at least one sibling in six families. The child probands shared A. actinomycetemcomitans clonal types with their parents in five of six (83%) families and with their siblings in three of six (50%) families. In the four parent-proband families, A. actinomycetemcomitans occurred in two spouses and all nine children. The parent probands shared A. actinomycetemcomitans clonal types with their spouses in both families and with their children in three of four families. In all families, the likelihood of intrafamilial transmission of A. actinomycetemcomitans was statistically significant. Members of most families (eight of 11, 73%) also harbored additional clonal types of A. actinomycetemcomitans. Conclusion: Parents and siblings of an individual with A. actinomycetemcomitans-positive AgP may have an increased susceptibility to periodontitis and shared and/or other clonal types of oral A. actinomycetemcomitans.
dc.identifier.doi10.1902/jop.2008.070270
dc.identifier.issn0022-3492
dc.identifier.pubmed18251645
dc.identifier.urihttps://hdl.handle.net/11424/229129
dc.identifier.wosWOS:000253185800015
dc.language.isoeng
dc.publisherAMER ACAD PERIODONTOLOGY
dc.relation.ispartofJOURNAL OF PERIODONTOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectActinobacillus actinomycetemcomitans
dc.subjectfamily
dc.subjectgenotype
dc.subjectperiodontitis
dc.subjectserotype
dc.subjecttransmission
dc.subjectLOCALIZED JUVENILE PERIODONTITIS
dc.subjectEARLY-ONSET PERIODONTITIS
dc.subjectPOLYMERASE-CHAIN-REACTION
dc.subjectALVEOLAR BONE LOSS
dc.subjectPORPHYROMONAS-GINGIVALIS
dc.subjectAGGRESSIVE PERIODONTITIS
dc.subjectADULT PERIODONTITIS
dc.subjectPOPULATION-STRUCTURE
dc.subjectGENETIC DIVERSITY
dc.subjectDISEASE
dc.titleConsistent intrafamilial transmission of actinobacillus actinomycetemcomitans despite clonal diversity
dc.typearticle
dspace.entity.typePublication
local.avesis.id4b356539-563a-41b3-8260-9d41df560cf4
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.endPage315
oaire.citation.issue2
oaire.citation.startPage307
oaire.citation.titleJOURNAL OF PERIODONTOLOGY
oaire.citation.volume79
relation.isAuthorOfPublicationa2569f78-7a2a-4f98-8cc9-d8b67ae56f6d
relation.isAuthorOfPublication.latestForDiscoverya2569f78-7a2a-4f98-8cc9-d8b67ae56f6d

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