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Effect of aging on the distribution of basic fibroblast growth factor immunoreactive cells in the rat hippocampus

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsSalik, E; Ercan, F; Sirvanci, S; Cetinel, S; Onat, F; San, T
dc.date.accessioned2022-03-12T17:18:58Z
dc.date.available2022-03-12T17:18:58Z
dc.date.issued2005
dc.description.abstractHippocampal formation is extremely sensitive to the aging process and appears to be one of the first regions to show structural and physiological changes with advancing age. Basic fibroblast growth factor (bFGF) plays an important role in the stimulation of mitogenesis in glial cells, the support of neuronal survival and the promotion of neurite outgrowth in vitro. In the present study, the effect of aging on the distribution of bFGF immunoreactive (bFGF-ir) cells was investigated. The protein product of bFGF was visualized immunohistochemically in the dorsal hippocampus of Wistar albino rats. bFGF-ir astrocytes in different subfields of hippocampus and neurons in CA2 field were quantified to determine whether changes in immunoreactivity were correlated with advancing age. Aging was accompanied by a decrease in bFGF-ir cell density in subfields of hippocampus. We concluded that aging was associated with a reduction in bFGF-ir cell density that may reflect a decreased expression of bFGF in the rat hippocampus. (C) 2004 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.brainresbull.2004.09.010
dc.identifier.eissn1873-2747
dc.identifier.issn0361-9230
dc.identifier.pubmed15607828
dc.identifier.urihttps://hdl.handle.net/11424/228039
dc.identifier.wosWOS:000226344200004
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofBRAIN RESEARCH BULLETIN
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectaging
dc.subjecthippocampus
dc.subjectbasic fibroblast growth factor
dc.subjectimmunohistochemistry
dc.subjectrat
dc.subjectBROWN-NORWAY RAT
dc.subjectAGED RATS
dc.subjectASTROCYTES
dc.subjectNEURONS
dc.subjectBRAIN
dc.subjectGLUTAMATE
dc.subjectEXPRESSION
dc.subjectSURVIVAL
dc.subjectDEFICITS
dc.titleEffect of aging on the distribution of basic fibroblast growth factor immunoreactive cells in the rat hippocampus
dc.typearticle
dspace.entity.typePublication
local.avesis.id7e179327-ef58-46ad-88b7-ae511fefc309
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage415
oaire.citation.issue5
oaire.citation.startPage409
oaire.citation.titleBRAIN RESEARCH BULLETIN
oaire.citation.volume64
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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