Publication:
Proteasome Inhibitors in Cancer Therapy and their Relation to Redox Regulation

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsSari, Gulce; Okat, Zehra; Sahin, Ali; Karademir, Betul
dc.date.accessioned2022-03-10T15:25:28Z
dc.date.available2022-03-10T15:25:28Z
dc.date.issued2018
dc.description.abstractRedox homeostasis is important for the maintenance of cell survival. Under physiological conditions, redox system works in a balance and involves activation of many signaling molecules. Regulation of redox balance via signaling molecules is achieved by different pathways and proteasomal system is a key pathway in this process. Importance of proteasomal system on signaling pathways has been investigated for many years. In this direction, many proteasome targeting molecules have been developed. Some of them are already in the clinic for cancer treatment and some are still under investigation to highlight underlying mechanisms. Although there are many studies done, molecular mechanisms of proteasome inhibitors and related signaling pathways need more detailed explanations. This review aims to discuss redox status and proteasomal system related signaling pathways. In addition, cancer therapies targeting proteasomal system and their effects on redox-related pathways have been summarized.
dc.identifier.doi10.2174/1381612825666190201120013
dc.identifier.eissn1873-4286
dc.identifier.issn1381-6128
dc.identifier.pubmed30706779
dc.identifier.urihttps://hdl.handle.net/11424/220256
dc.identifier.wosWOS:000462739300005
dc.language.isoeng
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.relation.ispartofCURRENT PHARMACEUTICAL DESIGN
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectProteasome inhibitors
dc.subjectredox status
dc.subjectsignaling molecules
dc.subjectcancer therapy
dc.subjectredox homeostasis
dc.subjectproteasomal system
dc.subjectNF-KAPPA-B
dc.subjectPROTEIN-KINASE-C
dc.subjectCELL LUNG-CANCER
dc.subjectHEAT-SHOCK RESPONSE
dc.subjectRETINOBLASTOMA PROTEIN
dc.subjectIN-VITRO
dc.subjectTRANSCRIPTIONAL REGULATION
dc.subjectIRREVERSIBLE INHIBITOR
dc.subjectSELECTIVE INHIBITORS
dc.subjectSIGNAL-TRANSDUCTION
dc.titleProteasome Inhibitors in Cancer Therapy and their Relation to Redox Regulation
dc.typereview
dspace.entity.typePublication
local.avesis.idca7a1226-6b1e-450c-8a6a-cd9c84da0753
local.import.packageSS5
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages16
local.journal.quartileQ3
oaire.citation.endPage5267
oaire.citation.issue44
oaire.citation.startPage5252
oaire.citation.titleCURRENT PHARMACEUTICAL DESIGN
oaire.citation.volume24
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

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