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Synthesis and Anticonvulsant Activity of New N-(Alkyl/Substituted aryl)-N '-[4-(5-cyclohexylamino)-1,3,4-thiadiazole-2-yl)pheny]thioureas

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dc.contributor.authorKAYMAKÇIOĞLU, BEDİA
dc.contributor.authorsKarakus, Sevgi; Kocyigit-Kaymakcioglu, Bedia; Toklu, Hale Z.; Aricioglu, Feyza; Rollas, Sevim
dc.date.accessioned2022-03-12T17:36:52Z
dc.date.available2022-03-12T17:36:52Z
dc.date.issued2009
dc.description.abstractA series of novel thiourea derivatives carrying the 5-cylohexylamino-1,3,4-thiadiazole moiety was synthesized and their anticonvulsant activity was evaluated. Structures of the synthesized compounds have been confirmed by IR, H-1-NMR, and elemental analysis. All of the compounds were administered at a dose of 50 mg/kg. Some of the active compounds have different effects in pentylenetetrazole (PTZ) and maximal electroshock (MES) tests, indicating the therapeutical potential in petit mal seizures, but not in grand mal seizures. Compounds 10, 11, 13, and 14 carrying 2-methylphenyl, 4-chlorophenyl, allyl, and 4-methylphenyl on the thiourea pharmacophore, increased the survival rate in the PTZ model. The ED50 values of the active compounds 10, 11, 13, and 14 were found 68.42, 43.75, 18.75 and 25 mg/kg, respectively.
dc.identifier.doi10.1002/ardp.200800118
dc.identifier.eissn1521-4184
dc.identifier.issn0365-6233
dc.identifier.pubmed19035387
dc.identifier.urihttps://hdl.handle.net/11424/229318
dc.identifier.wosWOS:000262871200006
dc.language.isoeng
dc.publisherWILEY-V C H VERLAG GMBH
dc.relation.ispartofARCHIV DER PHARMAZIE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnticonvulsant activity
dc.subjectMaximal electroshock seizure
dc.subjectPentylenetetrazole
dc.subject1,3,4-Thiadiazoles
dc.subjectThioureas
dc.subjectTHIOUREA DERIVATIVES
dc.subjectIN-VITRO
dc.subjectHIV
dc.subjectDESIGN
dc.subjectAGENTS
dc.titleSynthesis and Anticonvulsant Activity of New N-(Alkyl/Substituted aryl)-N '-[4-(5-cyclohexylamino)-1,3,4-thiadiazole-2-yl)pheny]thioureas
dc.typearticle
dspace.entity.typePublication
local.avesis.id94c69b11-d791-428d-b4cc-9820185b0884
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage53
oaire.citation.issue1
oaire.citation.startPage48
oaire.citation.titleARCHIV DER PHARMAZIE
oaire.citation.volume342
relation.isAuthorOfPublication0f8e7ba6-02e7-4232-84bb-31777a356761
relation.isAuthorOfPublication.latestForDiscovery0f8e7ba6-02e7-4232-84bb-31777a356761

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