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Fibroblast Growth Factor-23 Levels Are Associated with Vascular Calcifications in Peritoneal Dialysis Patients

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dc.contributor.authorVELİOĞLU, ARZU
dc.contributor.authorsAsicioglu, Ebru; Kahveci, Arzu; Arikan, Hakki; Koc, Mehmet; Tuglular, Serhan; Ozener, Cetin Ishak
dc.date.accessioned2022-03-14T10:55:32Z
dc.date.available2022-03-14T10:55:32Z
dc.date.issued2013
dc.description.abstractBackground: The aim of the study was to assess the relationship between fibroblast growth factor-23 (FGF-23) and vascular calcifications (VC) in peritoneal dialysis (PD) patients. Methods: A cross-sectional study was performed in 55 PD patients who underwent pelvic X-ray to assess for VC. Patients with and without linear calcifications were recorded. Results: Fifteen patients (27.3%) had linear calcifications on pelvic X-ray. FGF-23 levels were higher in patients with VC (299.5 (30.4-2,410.0) vs. 74.4 (14.8-1,030) pg/ml, p < 0.01). Diabetic patients had lower FGF-23 values (43.2 (14.9-134.0) vs. 103.5 (14.8-2,410) pg/ml, p < 0.01). Patients with residual renal function (RRF) had lower FGF-23 levels (70.6 (14.8-513) vs. 179.5 (30.4-2,410) pg/ml, p = 0.06); however, this did not reach statistical significance. FGF-23 levels, age, creatinine, Ca, dialysis duration and HbA1c were positively correlated with VC, whereas RRF, Ca intake and ALP were negatively associated. Multivariate logistic analysis confirmed FGF-23 levels, age, dialysis duration and RRF to be associated with VC. Conclusions: FGF-23 levels are associated with VC in PD patients. Further studies are needed to clarify whether it is simply a marker or a potential factor. It may prove to be an important therapeutic target for VC management. (C) 2013 S. Karger AG, Basel
dc.identifier.doi10.1159/000355859
dc.identifier.issn1660-2110
dc.identifier.pubmed24157489
dc.identifier.urihttps://hdl.handle.net/11424/245481
dc.identifier.wosWOS:000328704800013
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofNEPHRON CLINICAL PRACTICE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFibroblast growth factor-23
dc.subjectVascular calcifications
dc.subjectPeritoneal dialysis
dc.subjectCARDIOVASCULAR RISK
dc.subjectARTERIAL STIFFNESS
dc.subjectOBESE ADOLESCENTS
dc.subjectFGF-23
dc.subjectTHICKNESS
dc.subjectSCORE
dc.titleFibroblast Growth Factor-23 Levels Are Associated with Vascular Calcifications in Peritoneal Dialysis Patients
dc.typearticle
dspace.entity.typePublication
local.avesis.id6fe2151a-efd3-44a6-b0e2-f0a174e0dcb9
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage93
oaire.citation.issue1-2
oaire.citation.startPage89
oaire.citation.titleNEPHRON CLINICAL PRACTICE
oaire.citation.volume124
relation.isAuthorOfPublicationa7410f0e-0eb4-4b83-ad61-a71dfbee164f
relation.isAuthorOfPublication.latestForDiscoverya7410f0e-0eb4-4b83-ad61-a71dfbee164f

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