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Production and characterization of bacterial cellulose scaffold and its modification with hyaluronic acid and gelatin for glioblastoma cell culture

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dc.contributor.authorYILMAZ, BETÜL
dc.contributor.authorsUnal, Semra; Arslan, Sema; Yilmaz, Betul Karademir; Oktar, Faik Nuzhet; Sengil, Ahmet Zeki; Gunduz, Oguzhan
dc.date.accessioned2022-03-12T22:41:46Z
dc.date.available2022-03-12T22:41:46Z
dc.date.issued2021
dc.description.abstractThree-dimensional (3D) in vitro cell culture models have recently gained increasing interest in predicting the response of anticancer drugs. In this study first, we tried to obtain a novel hyaluronic acid (HA)/gelatin (Gel) modified bacterial cellulose (BC) composite scaffolds by in situ fermentation method. Morphological and chemical structures, wettability, and thermal stability of scaffolds were evaluated. In particular, the human glioblastoma (GBM) cancer cell line (U251) was seeded into BC/HA/Gel scaffolds to evaluate their potential as in vitro 3D cancer cell culture. MTT proliferation assay, scanning electron microscopy, and confocal microscopy were utilised to determine cell proliferation, morphology and adhesion. The results suggest that our hyaluronic acid and gelatin modified bacterial cellulose scaffold is promising to be used as in vitro 3D culture of GBM cells and may be used to predict treatment response or reactions of new therapeutics.
dc.identifier.doi10.1007/s10570-020-03528-5
dc.identifier.eissn1572-882X
dc.identifier.issn0969-0239
dc.identifier.urihttps://hdl.handle.net/11424/236161
dc.identifier.wosWOS:000582319600001
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofCELLULOSE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBacterial cellulose
dc.subjectHyaluronic acid
dc.subjectGelatin
dc.subjectGlioblastoma
dc.subject3D culture
dc.subjectGRAPHENE OXIDE
dc.subject3D
dc.subjectGLIOMA
dc.subjectNANOFIBERS
dc.subjectMIGRATION
dc.subjectPROLIFERATION
dc.subjectFABRICATION
dc.subjectRESISTANCE
dc.subjectMEMBRANES
dc.subjectBEHAVIOR
dc.titleProduction and characterization of bacterial cellulose scaffold and its modification with hyaluronic acid and gelatin for glioblastoma cell culture
dc.typearticle
dspace.entity.typePublication
local.avesis.idcfca6bce-8d88-4737-af74-9a4852306080
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages16
local.journal.quartileQ1
oaire.citation.endPage132
oaire.citation.issue1
oaire.citation.startPage117
oaire.citation.titleCELLULOSE
oaire.citation.volume28
relation.isAuthorOfPublication81633a07-e5fb-4760-b3ef-bf0878d87827
relation.isAuthorOfPublication.latestForDiscovery81633a07-e5fb-4760-b3ef-bf0878d87827

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