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Effects of ACE inhibition and AT(1)-receptor antagonism on endothelial function and insulin sensitivity in essential hypertensive patients

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dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsYavuz, D; Koc, M; Toprak, A; Akpinar, I; Velioglu, A; Deyneli, O; Haklar, G; Akalin, S
dc.date.accessioned2022-03-14T10:07:35Z
dc.date.available2022-03-14T10:07:35Z
dc.date.issued2003-09
dc.description.abstractObjective Disturbed endothelial function is closely associated with hyperinsulinaemia and insulin resistance in essential hypertension. The alms of this study were: 1) to evaluate whether the two alternative drugs, angiotensin-converting enzyme (ACE) inhibitors and Angiotensin 11 (Ang 11) antagonists, had comparable effects on glucose metabolism and endothelial function. 2) to determine whether they improve endothelial dysfunction through modulating insulin resistance and oxidative stress. Study design and methods Essential hypertensive patients were randomised into two groups: Twelve (nine patients in final analysis) patients were given enalapril (enalapril group), and twelve (nine patients in final analysis) were given losartan (losartan group). Twelve sex- and age-matched normotensive volunteers were included as controls. Before and after six months of treatment, endothelial function, insulin sensitivity and lipid peroxidation (TBARs) and NO metabolites (NOx) were evaluated. Results Endothelial function, measured as flow mediated dilatation (FMD), was improved in both of the treatment groups (p=0.0001). Calculated insulin sensitivity index also improved in the enalapril-treated group (p=0.05) but not in the losartan-treated group, compared with baseline levels. TBARS values decreased significantly in the enalapril group compared with baseline levels (p<0.001). FMD was positively correlated with insulin sensitivity index (r=0.32, p<0.05) and NOx levels (r=0.39, p=0.01) and negatively correlated with TBARS levels (r=-0.53, p=0.0002) in hypertensive patients. Conclusion Inhibition of the renin-angiotensin system, either with ACE inhibitors or AT(1)-receptor blockers improves endothelial dysfunction. ACE inhibition has prominent effects on improving insulin sensitivity and decreasing oxidative stress in essential hypertensive patients.
dc.identifier.doi10.3317/jraas.2003.032
dc.identifier.eissn1752-8976
dc.identifier.issn1470-3203
dc.identifier.pubmed14608527
dc.identifier.urihttps://hdl.handle.net/11424/244085
dc.identifier.wosWOS:000186440900013
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS LTD
dc.relation.ispartofJOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthypertension
dc.subjectangiotensin-converting enzyme inhibitors
dc.subjectangiotensin II receptor antagonists
dc.subjectinsulin resistance
dc.subjectvascular endothelium
dc.subjectoxidative stress
dc.subjectCONVERTING ENZYME-INHIBITORS
dc.subjectGLUCOSE-METABOLISM
dc.subjectNITRIC-OXIDE
dc.subjectANGIOTENSIN
dc.subjectDYSFUNCTION
dc.subjectRESISTANCE
dc.subjectKININS
dc.subjectTOLERANCE
dc.subjectLOSARTAN
dc.titleEffects of ACE inhibition and AT(1)-receptor antagonism on endothelial function and insulin sensitivity in essential hypertensive patients
dc.typearticle
dspace.entity.typePublication
local.avesis.id6dc78306-f826-4fbd-a46b-b71159553f4a
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage203
oaire.citation.issue3
oaire.citation.startPage197
oaire.citation.titleJOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
oaire.citation.volume4
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

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