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Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder

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dc.contributor.authorYILDIZ, MESUT
dc.contributor.authorsYildiz, Mesut; Celikel, Feryal Cam; Ates, Omer; Taycan, Serap Erdogan; Benli, Ismail; Demir, Osman
dc.date.accessioned2022-03-14T08:29:57Z
dc.date.available2022-03-14T08:29:57Z
dc.date.issued2017-06
dc.description.abstractBackground: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depression and bipolar disorder. Objective: The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depression and bipolar affective disorder. Methods: PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patients with major depression, and 100 patients with bipolar affective disorder and 96 healthy controls. Polymorphisms were analyzed by using polymerase chain reaction. Results: Our findings reported no association between Q192R and L55M polymorphisms of PON1 and major depression and bipolar disorder. Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolar patients. Discussion: Evaluating the different stages of patients with affective disorders and and investigating the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders.
dc.identifier.doi10.1590/0101-60830000000123
dc.identifier.eissn1806-938X
dc.identifier.issn0101-6083
dc.identifier.urihttps://hdl.handle.net/11424/241878
dc.identifier.wosWOS:000405461800005
dc.language.isoeng
dc.publisherUNIV SAO PAULO, INST PSIQUIATRIA
dc.relation.ispartofARCHIVES OF CLINICAL PSYCHIATRY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMajor depression
dc.subjectbipolar affective disorder
dc.subjectparaoxonase (PON1)
dc.subjectpolymorphism
dc.subjectassociation study
dc.subjectGENOME-WIDE ASSOCIATION
dc.subjectSERUM PARAOXONASE
dc.subject(PON)1 ACTIVITY
dc.subjectARYLESTERASE
dc.subjectGENE
dc.subjectPOPULATION
dc.subjectSTRESS
dc.subjectHEALTH
dc.subjectRISK
dc.titleParaoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder
dc.typearticle
dspace.entity.typePublication
local.avesis.ide5e352f3-0afa-4d05-a4d4-63f80bffecfa
local.import.packageSS16
local.indexed.atWOS
local.journal.numberofpages4
local.journal.quartileQ4
oaire.citation.endPage76
oaire.citation.issue3
oaire.citation.startPage73
oaire.citation.titleARCHIVES OF CLINICAL PSYCHIATRY
oaire.citation.volume44
relation.isAuthorOfPublication65166b6b-3dc1-4af5-bc24-41b7544cfa52
relation.isAuthorOfPublication.latestForDiscovery65166b6b-3dc1-4af5-bc24-41b7544cfa52

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