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Obesity is associated with IL-6 gene polymorphisms rs1800795 and rs1800796 but not SOCS3 rs4969170

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dc.contributor.authorULUCAN, KORKUT
dc.contributor.authorsKoc G., Doran T., Uygur M. M., Kirac D.
dc.date.accessioned2023-03-28T06:24:15Z
dc.date.available2023-03-28T06:24:15Z
dc.date.issued2023-03-01
dc.description.abstractBackground: An imbalance of inflammatory factors can stimulate obesity by inducing chronic inflammation in adipose tissue. Interleukin-6 (IL-6) is a cytokine with both inflammatory and anti-inflammatory functions. Suppressor of cytokine signaling 3 (SOCS3) acts as an inhibitor for a number of cytokine signals. The IL-6 and SOCS3 genes are known to be involved in lipid and energy metabolism, although it is unclear how these genes relate to obesity. The aim of this study is to determine whether the obesity risk is associated with the IL-6 (rs1800795, rs1800796) and SOCS3 (rs4969170) gene polymorphisms. Methods and results: Based on their body mass index (BMI) scores, 185 people were determined, of whom 90 were from the control group and 95 were obese. Anthropometric measurements and biochemical parameters of the study subjects were documented during the examination. Genomic DNA isolation was performed from the blood samples of all participants. IL-6 (rs1800795, rs1800796) and SOCS3 (rs4969170) polymorphisms were detected by real-time quantitative polymerase chain reaction (qRT-PCR) from genomic DNA samples. The IL-6 rs1800795 and rs1800796 variants showed a significant difference between the control and obese groups (p = 0.027; p = 0.013). The SOCS3 rs4969170 variation did not substantially differ between the control and obese groups (p = 0.825). Conclusion: In our study, IL-6 rs1800795(G/C) and rs1800796(G/C) polymorphisms appeared to be a risk factor for obesity. The C allele was associated with the obesity phenotypes. However, the SOCS3 rs4969170 (A/G) polymorphism was not linked to an increased risk of obesity. IL-6 polymorphisms may be new targets for obesity treatment.
dc.identifier.citationKoc G., Doran T., Uygur M. M., Kirac D., "Obesity is associated with IL-6 gene polymorphisms rs1800795 and rs1800796 but not SOCS3 rs4969170", Molecular Biology Reports, cilt.50, sa.3, ss.2041-2048, 2023
dc.identifier.doi10.1007/s11033-022-08129-y
dc.identifier.endpage2048
dc.identifier.issn0301-4851
dc.identifier.issue3
dc.identifier.startpage2041
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85144374518&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/287916
dc.identifier.volume50
dc.language.isoeng
dc.relation.ispartofMolecular Biology Reports
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Genetik
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectMedical Genetics
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectGENETİK VE KALITIM
dc.subjectLife Sciences (LIFE)
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectGENETICS & HEREDITY
dc.subjectMoleküler Biyoloji
dc.subjectGenetik
dc.subjectMolecular Biology
dc.subjectGenetics
dc.subjectIL-6
dc.subjectSOCS3
dc.subjectObesity
dc.subjectPolymorphism
dc.subjectINTERLEUKIN-6
dc.subjectINFLAMMATION
dc.subjectENERGY
dc.titleObesity is associated with IL-6 gene polymorphisms rs1800795 and rs1800796 but not SOCS3 rs4969170
dc.typearticle
dspace.entity.typePublication
local.avesis.idbba9cd47-757a-4ba8-aedf-0c96ca4e3649
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication46774657-48cb-4f47-a639-64e428a49411
relation.isAuthorOfPublication.latestForDiscovery46774657-48cb-4f47-a639-64e428a49411

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