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Enterogastric brake in rats with segmental bowel resection: Role of capsaicin-sensitive nerves

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsTopcu, T; Gulpinar, MA; Isman, CA; Yegen, BC; Yegen, C
dc.date.accessioned2022-03-12T16:58:42Z
dc.date.available2022-03-12T16:58:42Z
dc.date.issued2002
dc.description.abstract1. Unabsorbed nutrients in the distal gut inhibit upper gastrointestinal motility. 2. The aim of the present study was to investigate changes in gastric motility following segmental resections and to evaluate the role of capsaicin-sensitive afferent neurons that may be responsible for these changes. 3. Wistar albino rats of both sexes (200-250 g) were used. Under aseptic conditions and anaesthesia (100 mg/kg ketamine), a baby-feeding tube was placed distal to the resection in either the ileum or caecum for intraluminal perfusion of saline or 20% lipid. In one group of rats, capsaicin was perfused (0.6%) for afferent denervation. One group of rats underwent jejunal and ileal resections with end-to-end anastomosis of the remaining segments and were cannulated distal to these anastomosis. Ten days after the surgery, the percentage gastric emptying of a solid meal was calculated. 4. Intra-ileal (18%) and intracaecal (34%) lipid perfusions delayed gastric emptying compared with groups perfused with saline (54% and 74%, respectively; P < 0.001 and P < 0.01). The delay in gastric emptying by ileal perfusion was significantly greater than that following caecal perfusion (P < 0.05). With both resections, gastric emptying was delayed compared with sham groups (P < 0.05-0.01). Local administration of capsaicin abolished the inhibitory effect of lipid on gastric emptying in healthy intact rats and in the jejunal-resection group, whereas a partial reversal was seen in the ileal-resection group. 5. In conclusion, the present data demonstrate that in both healthy intact rat groups and in short bowel groups, capsaicin-sensitive extrinsic neurons participate in 'brake' mechanisms of the distal gut.
dc.identifier.doi10.1046/j.1440-1681.2002.03602.x
dc.identifier.eissn1440-1681
dc.identifier.issn0305-1870
dc.identifier.pubmed11917906
dc.identifier.urihttps://hdl.handle.net/11424/227092
dc.identifier.wosWOS:000175397400010
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcapsaicin
dc.subjectenterogastric brake
dc.subjectgastric emptying
dc.subjectintestinal resection
dc.subjectshort bowel
dc.subjectPEPTIDE-YY
dc.subjectILEAL BRAKE
dc.subjectCOLONIC BRAKE
dc.subjectINTESTINAL TRANSIT
dc.subjectJEJUNAL MOTILITY
dc.subjectFAT
dc.subjectRELEASE
dc.subjectGUT
dc.subjectENTEROGLUCAGON
dc.subjectINHIBITION
dc.titleEnterogastric brake in rats with segmental bowel resection: Role of capsaicin-sensitive nerves
dc.typearticle
dspace.entity.typePublication
local.avesis.idb2439bea-3bc7-499f-a740-e776476bfdfb
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage72
oaire.citation.issue1-2
oaire.citation.startPage68
oaire.citation.titleCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
oaire.citation.volume29
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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