Publication:
The Impacts of the Physiological Changes Occurring During Pregnancy on Pharmacokinetic Mechanisms

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dc.contributor.authorAKICI, AHMET
dc.contributor.authorsAkici, Ahmet; Tamirci, Mevhibe; Goren, Mehmet Zafer
dc.date.accessioned2022-03-10T15:25:23Z
dc.date.available2022-03-10T15:25:23Z
dc.date.issued2017
dc.description.abstractAlthough pharmacotherapy is avoided due to risks during pregnancy, sometimes drugs may be required for specific clinical conditions. Inappropriate use because of limited available information may lead to malpractice. Health professionals, especially physicians, should have a better knowledge of the fact that drug use in pregnant women has some important differences from that in normal adults. Thus, they must comply with these specific requirements. One of the major differences is the change in drug pharmacokinetics during pregnancy. Important changes related to drug absorption, distribution, metabolism, and elimination show wide variability in maternal body, placenta, embryo, and fetus. These changes determine the selection of drug, its dose, and duration of its use. The successful management of treatment process during pregnancy is difficult and sometimes requires professional support due to confounding reasons, including individual factors, gestational age, mothers' age, and underlying diseases and their impact on drug metabolism. Therefore, health professionals and patients are required to get better benefit from sources, especially from clinical pharmacology information services. The present review discusses the details of how and to what extent the pharmacokinetic mechanisms are affected by the physiological changes that occur during pregnancy and their interpretation to clinical conditions.
dc.identifier.doi10.5152/clinexphealthsci.2017.174
dc.identifier.issn2459-1459
dc.identifier.urihttps://hdl.handle.net/11424/220226
dc.identifier.wosWOS:000414421700006
dc.language.isotur
dc.publisherMARMARA UNIV, INST HEALTH SCIENCES
dc.relation.ispartofCLINICAL AND EXPERIMENTAL HEALTH SCIENCES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGestation
dc.subjectpharmacokinetics
dc.subjectmaternal
dc.subjectphysiological changes
dc.subjectplacental transfer
dc.subjectCYP2D6
dc.titleThe Impacts of the Physiological Changes Occurring During Pregnancy on Pharmacokinetic Mechanisms
dc.typereview
dspace.entity.typePublication
local.avesis.iddaabc317-b663-46ee-b8dd-16afd4b05e27
local.import.packageSS5
local.indexed.atWOS
local.indexed.atTRDIZIN
local.journal.numberofpages7
oaire.citation.endPage77
oaire.citation.issue2
oaire.citation.startPage71
oaire.citation.titleCLINICAL AND EXPERIMENTAL HEALTH SCIENCES
oaire.citation.volume7
relation.isAuthorOfPublication6c7c9f26-63a9-4f6f-91cd-aa9e3452919c
relation.isAuthorOfPublication.latestForDiscovery6c7c9f26-63a9-4f6f-91cd-aa9e3452919c

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