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New insights into the in vitro biological effects, in silico docking and chemical profile of clary sage - Salvia sclarea L.

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dc.contributor.authorDOĞAN, AHMET
dc.contributor.authorsZengin, Gokhan; Senkardes, Ismail; Mollica, Adriano; Picot-Allain, Carene Marie Nancy; Bulut, Gizem; Dogan, Ahmet; Mahomoodally, M. Fawzi
dc.date.accessioned2022-03-12T22:27:18Z
dc.date.available2022-03-12T22:27:18Z
dc.date.issued2018
dc.description.abstractSalvia sclarea L. is traditionally used to manage common human ailments and is consumed as a food product. This study aimed to establish the phytochemical profile and antioxidant potential of ethyl acetate, methanol, and water extracts of Salvia sclarea. The inhibitory action of the extracts against alpha-amylase, alpha-glucosidase, acetyicholinesterase, butyrylcholinesterase, and tyrosinase was also investigated. Methanol extract showed the highest phenolic and fiavonoid contents (81.78 mg GAE/g extract and 40.59 mg RE/g extract, respectively). Reversed phase high performance liquid chromatography with diode array detector analysis revealed that S. sclarea was rich in rosmarinic acid. The water extract exhibited the lowest inhibitory activity against alpha-amylase but the upmost activity against alpha-glucosidase (0.19 and 18.24 mmol ACAE/g extract, respectively). Experimental data showed that only the water extract (8.86 mg KAE/g extract) significantly inhibited tyrosinase. Docking studies showed that quercetin binds to tyrosinase by two hydrogen and a pi-pi bonds. Salvia sclarea showed interesting biological activity against key enzymes involved in the pathogenesis of common ailments. (C) 2018 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.compbiolchem.2018.05.005
dc.identifier.eissn1476-928X
dc.identifier.issn1476-9271
dc.identifier.pubmed29772456
dc.identifier.urihttps://hdl.handle.net/11424/235185
dc.identifier.wosWOS:000437057500013
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofCOMPUTATIONAL BIOLOGY AND CHEMISTRY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSalvia
dc.subjectClary sage
dc.subjectNatural enzyme inhibitors
dc.subjectMolecular docking
dc.subjectTOTAL FLAVONOID CONTENT
dc.subjectALPHA-GLUCOSIDASE
dc.subjectROSMARINIC ACID
dc.subjectALZHEIMERS-DISEASE
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectANTIMICROBIAL ACTIVITY
dc.subjectPHYTOCHEMICAL PROFILE
dc.subjectINHIBITORY-ACTIVITIES
dc.subjectESSENTIAL OIL
dc.subjectTYROSINASE
dc.titleNew insights into the in vitro biological effects, in silico docking and chemical profile of clary sage - Salvia sclarea L.
dc.typearticle
dspace.entity.typePublication
local.avesis.idfa842cd6-0c25-4aac-ae0b-dd352bd2618e
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
local.journal.quartileQ3
oaire.citation.endPage119
oaire.citation.startPage111
oaire.citation.titleCOMPUTATIONAL BIOLOGY AND CHEMISTRY
oaire.citation.volume75
relation.isAuthorOfPublication34e928c8-270a-41b3-8311-23fba8b897ed
relation.isAuthorOfPublication.latestForDiscovery34e928c8-270a-41b3-8311-23fba8b897ed

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