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Synergistic Effects of Methotrexate and Suberoylanilide Hydroxamic Acid in Triggering Apoptosis of Chronic Myeloid Leukemia Cells

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dc.contributor.authorYALÇIN, AHMET SUHA
dc.contributor.authorsAltundag, Ergul M.; Yilmaz, Ayse M.; Corek, Ceyda; Yalcin, A. Suha; Taga, Yavuz; Kocturk, Semra
dc.date.accessioned2022-03-14T11:07:02Z
dc.date.available2022-03-14T11:07:02Z
dc.date.issued2015-03-30
dc.description.abstractIn this study, we have investigated the effects of suberoylanilide hydroxamic acid (SAHA) against chronic myeloid leukemia (CML) cells in combination studies with methotrexate (MTX), which is a dihydrofolate reductase inhibitor used in combination therapy with other agents or alone. Combination of synergistic ratios of MTX and SAHA led to apoptotic cell death of CML cells via PARR cleavage, cytochrome c release and ROS increase in vitro. We suggest that combination of MD( and SAHA may minimize the toxicity and side effects of SAHA treatment, thus providing lower amounts of each drug in CML treatment.
dc.identifier.doi10.4999/uhod.15634
dc.identifier.issn1306-133X
dc.identifier.urihttps://hdl.handle.net/11424/245908
dc.identifier.wosWOS:000352253400001
dc.language.isoeng
dc.publisherAKAD DOKTORLAR YAYINEVI
dc.relation.ispartofUHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChronic myeloid leukemia
dc.subjectMethotrexate
dc.subjectSuberoylanilide hydroxamic acid
dc.subjectApoptosis
dc.subjectHISTONE DEACETYLASE INHIBITOR
dc.subjectACUTE LYMPHOBLASTIC-LEUKEMIA
dc.subjectCOMBINATION THERAPY
dc.subjectHDAC INHIBITORS
dc.subjectCANCER-THERAPY
dc.subjectEXPRESSION
dc.subjectACETYLATION
dc.subjectGENE
dc.subjectSAHA
dc.subjectPROLIFERATION
dc.titleSynergistic Effects of Methotrexate and Suberoylanilide Hydroxamic Acid in Triggering Apoptosis of Chronic Myeloid Leukemia Cells
dc.typearticle
dspace.entity.typePublication
local.avesis.id3253c56a-5f3e-4cb8-b78e-8a019dcec4b4
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
local.journal.numberofpages11
oaire.citation.endPage11
oaire.citation.issue1
oaire.citation.startPage1
oaire.citation.titleUHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
oaire.citation.volume25
relation.isAuthorOfPublication7a2bc583-aab6-43e7-9cc3-0d7a60773409
relation.isAuthorOfPublication.latestForDiscovery7a2bc583-aab6-43e7-9cc3-0d7a60773409

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